| 项目编号: | 1553831
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| 项目名称: | CAREER: Engineering multilamellar vaccine platforms for vaccination against HIV |
| 作者: | James Moon
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| 承担单位: | University of Michigan Ann Arbor
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2021-06-30
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| 资助金额: | 504991
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | vaccine delivery system
; hiv
; hiv candidate antigen
; biomaterial
; vaccine development
; vaccine component
; career application
; investigator
; multilamellar vaccine platform
; mucosal tissue
; hiv vaccine design
; mucosal vaccination
; vaccine design
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| 英文摘要: | PI: Moon, James
Proposal Number: 1553831
Mucosal tissues are the major portal of entry and initial sites of infection for many pathogens, including human immunodeficiency virus (HIV). However, there is no methodology currently available that can elicit protective immunity in mucosal tissues in a safe and effective manner. The investigator?s long-term goal is to develop novel biomaterial-based approaches for vaccination against infectious pathogens. In this CAREER application, the investigator proposes to address this global challenge by investigating the impact of material properties of vaccine delivery systems on immune activation in mucosal lymphoid tissues. The new knowledge gained through this interdisciplinary effort will advance the understanding of immune responses to biomaterials and address current technical challenges facing vaccine development.
The overall goal of the project is to test the hypothesis that ?pathogen-mimicking? nanomaterials engineered for optimized delivery of vaccine components to mucosal lymphoid tissues will induce robust, concerted T and B cell immune responses in mucosal tissues. To achieve this, the investigator will develop a series of multilamellar vaccine platforms (MVPs), employ HIV candidate antigens, and define structure-function relationships that govern the interaction between biomaterials and the immune system in cellular, tissue, and organism levels in murine models of mucosal vaccination. The proposed studies will (1) generate new information on how material properties of vaccine delivery systems dictate antigen delivery and presentation, (2) shed new light on new nanomaterial-based approaches to modulate mucosal immunity, (3) dissect the role of nanocarriers on innate and adaptive immunity, and (4) delineate pathways to safely elicit protective immunity against HIV. Furthermore, the MVP technology established in this project could be easily adopted to other infectious pathogens, thus broadening the scope of the work beyond HIV vaccine design and impacting a wide range of disciplines, including biomaterials, drug delivery, and immunology. The investigator also seeks to integrate research with educational activities designed to raise excitement and interest in the emerging field of nanoscience. This will be achieved by (a) engaging underrepresented minorities and women to pursue careers in science and engineering; (b) training undergraduate and graduate students in the investigator?s laboratory; and (c) communicating research to the general public. The broader public, particularly underrepresented high school students in a low-income area of Detroit, will be reached by developing a series of new Saturday morning workshops, entitled ?MVPs in Michigan, which will feature science demonstrations on nanotechnology, nanomedicine, and vaccine design. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91815
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
James Moon. CAREER: Engineering multilamellar vaccine platforms for vaccination against HIV. 2016-01-01.
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