| 项目编号: | 1642287
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| 项目名称: | CAREER: High-throughput Imaging of Drug Response in Tumor Organoids |
| 作者: | Melissa Skala
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| 承担单位: | Morgridge Institute for Research, Inc.
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2021-04-30
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| 资助金额: | 509451
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | tumor response
; multiple drug
; drug treatment
; drug response
; imaging nadh
; optical imaging
; tumor cell
; interference light sheet fourier fluorescence lifetime imaging microscopy
; high-throughput imaging technology
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| 英文摘要: | ABSTRACT
PI: Scala, Melissa
Proposal: 1554027
The proposal focuses on developing a high-throughput imaging technology to measure drug response and cellular metabolism in tumor cells cultured with cells in their native environment. The data obtained will be used to predict tumor response to multiple drugs, providing information that can be used to optimize drug treatment for the individual cancer patient. The Educational Plan, which includes a new undergraduate course in optical imaging, has a strong emphasis on outreach activities directed at middle and high school students and girls.
Interference light sheet Fourier Fluorescence lifetime imaging microscopy (iLS-FP-FLIM) will be created and information obtained by imaging NADH and FAD coenzymes in human breast cancer cells grown in a mouse model. This will be used to predict tumor response to multiple drugs, providing information that can be used to optimize drug treatment for the individual cancer patient. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91816
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Melissa Skala. CAREER: High-throughput Imaging of Drug Response in Tumor Organoids. 2016-01-01.
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