| 项目编号: | 1554200
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| 项目名称: | CAREER: Time-domain encoded optofluidics for highly multiplexed pathogen detection |
| 作者: | David Issadore
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| 承担单位: | University of Pennsylvania
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2021-06-30
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| 资助金额: | 510000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | barcode detection
; time consuming
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| 英文摘要: | Abstract
PI: Issadore, David
Proposal: 1554200
The objective of this proposal is to develop a new technological platform for reading out multiple fluorescence droplet based assays on microfluidic chips. The proposed technology could have significant impact in medical diagnostics, environmental surveillance, and bio/chemical warfare defense. The project educational program is well thought out and includes development of a senior design course on the appropriate point of care diagnostics for rural medicine in underserved countries.
The key innovation is amplitude modulated encoding of the fluorescence signal generated by a droplet passing through a microfluidic channel using a distinct micro-patterned (barcoded) mask for each of the channels. This may solve the problem of detecting each droplet individually, which is very time consuming. Instead, all droplets are detected in parallel followed by signal decomposition based on the barcode. This is elegant and innovative. The PI proposes to adopt the device for barcode detection of pathogens in water. This is clearly a problem of very high importance, especially in field conditions in the developing world. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91824
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
David Issadore. CAREER: Time-domain encoded optofluidics for highly multiplexed pathogen detection. 2016-01-01.
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