| 项目编号: | 1604531
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| 项目名称: | Collaborative Research: In vivo Deep Tissue Imaging with Ultrafast, Volumetric Super-Resolution Microscopy |
| 作者: | Leslie Ying
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| 承担单位: | SUNY at Buffalo
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | 232844
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | super-resolution
; high specificity imaging tool
; sub-diffraction-limited resolution
; super-resolution investigation
; stochastic optical reconstruction microscopy
; super-resolution spectroscopy advance
; understanding
; ultrafast super-resolution microscopy
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| 英文摘要: | Jia, Shu / Ying, Leslie
1604565 / 1604531
This work will advance the discovery and understanding of the brain, improve healthcare, and enhance infrastructure for research and education. The project will lay the foundation for a better understanding of neurodegenerative diseases such as Alzheimer's in both biological and clinical investigations. The super-resolution spectroscopy advances will provide fast, molecular level, non-invasive, high specificity imaging tools for translational medical applications.
This project will develop a new volumetric, ultrafast super-resolution microscopy to overcome technical barriers for in vivo investigations of tissue and organ functions. Switching methods, such as stochastic optical reconstruction microscopy (STORM) rely on imaging of single molecules to reconstruct fluorescence images with sub-diffraction-limited resolution. The roles of microglia in response to Ab (Amyloid beta) are crucially involved in the diseased (AD) brain; and ultimately provide tools and solutions for clinical investigations. The proposed super-resolution investigation will provide new insights into the role of microglia to the maintenance of brain function and in response to pathological insults. The proposed work will pave the technological and intellectual foundation for deeper understanding of the microglial response and influence to neurodegenerative disorders. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91863
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Leslie Ying. Collaborative Research: In vivo Deep Tissue Imaging with Ultrafast, Volumetric Super-Resolution Microscopy. 2016-01-01.
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