| 项目编号: | 1601699
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| 项目名称: | DISSERTATION RESEARCH: Gene Regulation Evolution and Speciation in House Mice |
| 作者: | Michael Nachman
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| 承担单位: | University of California-Berkeley
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2018-06-30
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| 资助金额: | 20357
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | gene regulation
; house mouse subspecy
; regulatory evolution
; specific gene
; house mouse
; reproductive isolation
; speciation process
; dissertation work
; genetic difference
; speciation research
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| 英文摘要: | This project will make use of controlled laboratory experiments utilizing the model system of house mice (Mus musculus) to understand the role of gene regulation in speciation. A primary goal of speciation research is to uncover the genetic differences between species that underlie reproductive isolation. While much of the work in this field has focused on identifying specific genes that contribute to reproductive isolation between species, gene regulation may play a large role in this process. Despite this, there are been few systematic attempts to link regulatory evolution to reproductive isolation. Characterizing regulatory evolution between house mouse subspecies will provide novel insight into how regulatory networks evolve and diverge which has broad implications for our understanding of the evolution of complex phenotypes as well as the speciation process. In addition, the investigators will engage in research with undergraduates from underrepresented groups and provide public and K12 outreach on this project.
Taking advantage of a cross between house mouse subspecies, where hybrid dysfunction is largely unidirectional, the proposed work will use a variety of genomic methods (i.e., ChiP-sequencing, mRNA-sequencing, and ribosome profiling) to characterize changes in gene regulation on the transcriptional and translational level that are associated with hybrid sterility. This dissertation work will address the following questions: 1) What is the role of different levels of gene regulation to species divergence? and 2) What is the role of regulatory divergence in reproductive isolation between species? The work outlined here will be the first to: 1) characterize divergence in translational efficiency between mammalian species, and 2) examine the relationship between hybrid sterility and gene regulation on the transcriptional and translational level. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91917
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Michael Nachman. DISSERTATION RESEARCH: Gene Regulation Evolution and Speciation in House Mice. 2016-01-01.
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