| 项目编号: | 1605116
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| 项目名称: | Early Non-Invasive Diagnosis of Liver Disease with Optical Spectroscopy |
| 作者: | Lev Perelman
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| 承担单位: | Beth Israel Deaconess Medical Center
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | 660000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | non-invasive
; liver disease
; non-invasive clinical optical spectroscopy system
; liver fibrosis
; liver diagnostic information
; non-invasive liver monitoring
; diffuse optical spectroscopy
; invasive liver biopsy
; optical spectroscopy
; non-invasive optical spectroscopic method
; optical spectroscopic system
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| 英文摘要: | ABSTRACT
Perelman, Lev; 1605116
The clinical management of patients with liver disease is a major challenge due to the absence of accurate non-invasive clinical tests. Some medications have shown promise for reversing liver fibrosis and cirrhosis, however there is a large barrier in testing these medications in people because treatment evaluation requires either invasive liver biopsy or post-mortem evaluation. This project will develop an optical spectroscopic system for non-invasive liver monitoring and will have a broad impact in hepatology. The project will provide Ph.D. thesis projects for Biological and Biomedical Sciences (BBS) Program students at Harvard Medical School and also the Harvard-MIT Division of Health Sciences and Technology (HST) students. The PI will augment courses at Harvard to introduce the principles of diffuse optical spectroscopy. Portions of instrument development and design will be made available by the PI for student projects within the biomedical engineering senior design course instructed at BU.
The PI has shown that optical spectroscopy can obtain liver diagnostic information in mice by quantifying scattering and absorption properties due to hemoglobin, cytochromes, fat, and collagen. In order to proceed to human use the project will develop non-invasive optical spectroscopic methods for correlating alterations in these properties with liver disease, with the goal of providing an accurate diagnostic method appropriate for humans. First techniques for animal use will allow studying diagnostic parameters in all the applicable models of liver disease. Then they will develop a non-invasive clinical optical spectroscopy system and will test it in vivo in human subjects. This involves development of a non-invasive fiber based probe for liver disease by measuring spectroscopic parameters related to portal hypertension. Numerical modeling will use Monte Carlo techniques to model light propagation through media layers. Experimental measurements on multilayered phantoms will be used to validate the models. Specific tasks include: (1) Instrumentation Development and Testing in Tissue Phantoms; (2) Physical Model and Algorithm for Non-Invasive in Vivo Measurements; and (3) Animal and Human Experiments. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91948
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Lev Perelman. Early Non-Invasive Diagnosis of Liver Disease with Optical Spectroscopy. 2016-01-01.
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