| 项目编号: | 1604308
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| 项目名称: | Network Hemodynamics: A Computational Study of Cellular Blood Flow and Particulate Transport in Microvascular Capillary Networks |
| 作者: | Prosenjit Bagchi
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| 承担单位: | Rutgers University New Brunswick
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| 批准年: | 2016
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| 开始日期: | 2016-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | 383491
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | blood flow
; network architecture
; network
; blood cell
; self-sustained flow oscillation
; poly-disperse blood cell
; network flow resistance
; time-dependent flow variation
; red blood cell
; vessel network
; blood clot
; blood-handling device
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| 英文摘要: | CBET - 1604308
PI: Bagchi, Prosenjit
This award provides for support for numerical simulations and microfluidics-based experiments to study blood flow in small vessels and to examine the distribution of red blood cells among various branches of the vascular tree. Although this is a long-standing problem, the combination of advanced computations and experiments will provide new insights to help explain observations reported in the literature over decades. The numerical computations will examine the partitioning of red cells at vessel bifurcations where a vessel splits into two vessels and at locations where vessels recombine. The simulations will also examine time-dependent flow variations that are intrinsic to flow through vessel networks. Results from simulations will be compared with experiments of blood flow through microfluidic channels and networks of channels. The results of the project will be useful to scientists and engineers who work in areas such as tissue engineering, intravenous drug delivery, and in the design of blood-handling devices. The research will be incorporated into a summer course for high-school students titled "Computational Methods in Science and Engineering." Undergraduates, especially those from underrepresented groups, will be recruited to participate in the research.
A three-dimensional, multiscale direct numerical simulation will be developed for deformable, poly-disperse blood cells flowing through networks of bifurcating, merging, and tortuous vessels. The model will include evolving cellular interfaces governed by hyper-viscoelastic constitutive laws and intricate stationary boundaries defined by the network architecture. The overall model will combine an immersed boundary method, a finite element method for interface deformation and a stochastic Monte-Carlo method for coarse-graining molecular interactions. The model will be validated by comparison with experiments of blood flow in networks of microfluidic channels. These tools will be used to examine the influence of network architecture on the distribution of blood cells, the network flow resistance, and the growth of self-sustained flow oscillations. The model will also be used to examine the influence of network architecture on the formation of blood clots and on deposition of drug-bearing particles. The results of this project will provide an organ-scale model of blood flow that retains cellular-scale dynamics. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/91980
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Prosenjit Bagchi. Network Hemodynamics: A Computational Study of Cellular Blood Flow and Particulate Transport in Microvascular Capillary Networks. 2016-01-01.
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