| 项目编号: | 1640780
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| 项目名称: | RAPID: Environmental drivers of Zika transmission and control |
| 作者: | Courtney Murdock
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| 承担单位: | University of Georgia Research Foundation Inc
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| 批准年: | 2016
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| 开始日期: | 2016-05-01
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| 结束日期: | 2018-04-30
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| 资助金额: | 200000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | transmission potential
; zika
; zika virus
; zika transmission
; transmission relationship
; mosquito control efficiency
; zika viral dynamics
; project
; rapid award
; control measure
; geographic zika transmission model
; zika public health emergency
; disease transmission
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| 英文摘要: | This RAPID award will address gaps in our knowledge about i) the time it takes for the Zika virus to become infectious in a mosquito, ii) the proportion of a mosquito population that becomes infectious, and iii) mosquito survival in the two Aedes species shown to transmit the Zika virus, species that are also found in the United States. To predict the seasonal and geographic distribution of potential outbreaks, the project will examine temperature and transmission relationships that can alter viral dynamics in the mosquito. This study will enhance our understanding of how Zika and other pathogens are transmitted and will help in the design of control measures. There is an urgent need to understand and predict the emergence and transmission potential of Zika because of its unique characteristics, e.g., fetal abnormalities and the potential of transporting Zika to new regions of the world, including the United States. Results from this project will be relevant to the Zika public health emergency, and the researchers have set in place mechanisms to share quality-assured interim and final data as rapidly and widely as possible, including with public health and research communities.
This project will characterize Zika viral dynamics, which impact the transmission potential. The study will evaluate the extrinsic incubation period (EIP), vector competence, and mosquito survival in field-derived Aedes aegypti and A. albopictus. These characteristics will be examined using a range of viral doses reflective of asymptomatic and symptomatic human infections. The study investigates the relationship between temperature and transmission potential to predict the seasonal and geographic Zika transmission models for these two species. From these results, predictive models of Zika transmission and sensitivity analyses will be used to assess mosquito control efficiency. Ultimately, this project will produce a framework for assessing sources of environmental, genetic, and anthropogenic variation that influence disease transmission and risk from these mosquitos. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/92482
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Courtney Murdock. RAPID: Environmental drivers of Zika transmission and control. 2016-01-01.
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