| 项目编号: | 1557102
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| 项目名称: | Collaborative Research: Phylogenomics and evolutionary history of the anaerobic fungal group, Neocallimastigomycota |
| 作者: | Noha Youssef
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| 承担单位: | Oklahoma State University
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| 批准年: | 2016
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| 开始日期: | 2016-04-01
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| 结束日期: | 2019-03-31
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| 资助金额: | 392602
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | genome
; evolutionary history
; research
; underrepresented group
; peculiar group
; overall research progress
; fungal group
; biofuel research
; extensive phylogenomic analysis
; other fungal group
; other group
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| 英文摘要: | The anaerobic gut fungi differ from all other groups of fungi in two ways: they grow in the absence of oxygen, and they grow in a restricted habitat (the rumen and alimentary tract of plant eating animals). They evolved hundreds of millions of years ago and represent one of the oldest fungal groups, yet their evolutionary history is unclear. Specifically, the exact relationship between anaerobic fungi and other fungal groups, as well as the timing and sequence of events that lead to their localization to a gut habitat, remains unclear. Further, it is not exactly known how the gut habitat has affected their genomes and evolution. This project will tackle these questions by sequencing the genomes of a large, diverse collection of anaerobic gut fungi, and analyzing the data produced using a wide range of computational procedures. The proposed efforts will lead to significant advances in the understanding of the history of this peculiar group of fungi and factors driving their evolution. Further, the data obtained would be of extreme interest to a broader group of scientists working in the areas of biofuel research, animal nutrition, and molecular biology of fungi. The project will engage multiple high school and undergraduate students in research, with special effort to engage minority (especially Native American) students to advance the participation of underrepresented groups in science, technology, and math disciplines.
Overall research progress on anaerobic fungi has been slow, and sequencing of anaerobic gut fungi (AGF) genomes has been hampered by their extremely high adenine-thymine content and the proliferation of intergenic repeats in their genomes. This project will utilize a new approach that combines multiple sequencing technologies to sequence the genomes and transcriptomes of a large and diverse collection of anaerobic fungal isolates. This research will utilize the data generated to conduct an extensive phylogenomic analysis, aiming to resolve their evolutionary history within the fungal tree of life, correlate the timing of AGF diversification events to the evolution of their herbivorous hosts, resolve the diversification pattern of anaerobic fungal genera, and investigate the impact of the unique habitat and evolutionary trajectory on their genomic architecture. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/92594
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Noha Youssef. Collaborative Research: Phylogenomics and evolutionary history of the anaerobic fungal group, Neocallimastigomycota. 2016-01-01.
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