| 项目编号: | 1555769
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| 项目名称: | COLLABORATIVE RESEARCH: NSFDEB-BSF: Quantifying genomic porosity in non-model radiations |
| 作者: | Adam Siepel
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| 承担单位: | Cold Spring Harbor Laboratory
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| 批准年: | 2016
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| 开始日期: | 2016-03-01
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| 结束日期: | 2019-02-28
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| 资助金额: | 197334
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | species
; rapid radiation
; researcher
; project
; research community
; research team
; avian radiation
; biological research
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| 英文摘要: | Understanding how organisms are related to each other is a central goal of biological research, yet much of the branching structure of the tree of life remains imperfectly known. Comparisons of DNA sequences have been used to build reliable evolutionary trees for many groups of organisms. Yet in cases where species hybridize with one another (or have done so in the past), their descendants become a mosaic of genetic backgrounds, and this genetic mixing makes it more difficult to back-calculate their past relationships. Hybridization is particularly common in groups of species that have undergone rapid radiations - situations when large numbers of species evolve over a relatively short period of time - while at the same time these rapid radiations are models for many other kinds of evolutionary analysis. This project will investigate the type of genomic regions that are exchanged among species during rapid radiations. A central goal of the researchers is to develop a computer program that leverages large-scale genomic data to better understand the phylogenetic relationships among species, improving the ability to incorporate the effects of past hybridization events. This tool will be made available to the research community to help biologists understand evolution at the tips of the tree of life. The project will add interactive multimedia-based modules on phylogenetics and systematics to the highly successful All About Bird Biology website. The project is a funded collaboratively by the NSF and the Binational Science Foundation of Israel.
The overarching goals of this project are to test questions about the degree and type of genomic regions exchanged among species in rapid radiations, and to explore the implications for phylogenetic inference. These objectives are based on the further development of a new bioinformatics tool (Generalized Phylogenetic Coalescent Sampler - G-PhoCS) that will allow scientists studying non-model organisms to test hypotheses about phylogenetic relationships and generate detailed demographic inferences (e.g., quantifying gene flow, effective population sizes and divergence times) across a phylogeny, using a variety of genomic-scale datasets. As empirical test cases, the researchers will leverage natural evolutionary experiments in two avian radiations in which pairs of species can be classified as either introgression-prone or introgression-resistant based on external criteria such as ecological overlap and sympatry/allopatry. The research team brings together systematists and computer scientists attempting to realize the full potential of newly emerging high throughput sequence data by developing inference methods that make use of the rich information they provide. This collaboration will more generally broaden the understanding of the patterns and processes underlying genealogical discordance among regions of the genome. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/92789
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| Appears in Collections: | 全球变化的国际研究计划
科学计划与规划
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| Recommended Citation: | |
Adam Siepel. COLLABORATIVE RESEARCH: NSFDEB-BSF: Quantifying genomic porosity in non-model radiations. 2016-01-01.
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