| 项目编号: | 1445684
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| 项目名称: | NSF/FDA SIR: Bioimpedance of stimulating electrodes for the safe placement of retinal implants |
| 作者: | Nathalia Peixoto
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| 承担单位: | George Mason University
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| 批准年: | 2014
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| 开始日期: | 2015-09-01
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| 结束日期: | 2017-08-31
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| 资助金额: | USD100018
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | electrode
; retina
; retinal implant
; stimulus electrode array
; electrode proximity
; safe placement
; electrode touch
; retinal stimulus electrode
; stimulus electrode
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| 英文摘要: | PI: Peixoto, Nathalia L
Proposal: 1445684
Title: Bioimpedance of stimulating electrodes for the safe placement of retinal implants
Significance
This project may provide society are a better understanding of the design issues that cause a loss of effectiveness of retinal stimulus electrodes in blind subjects. In retinal implants, the distance between the stimulating electrode and the surface of the retina is a critical variable for determining perceptual thresholds and for implant safety in general. When the electrode is too far from the target ganglion cells, the current density achieved in the retina is low, in part due to current spreading through the vitreous humour, thus raising the perceptual threshold and therefore decreasing spatial resolution. If, on the other hand, the electrode touches the retina, mechanical damage can be expected. There is therefore a need to determine the distance from the electrode to the retina in situ. The PI proposes to investigate methods to reliably measure electrode proximity to the retina, with the objective of establishing techniques which are readily translatable to current technology.
Technical Description
Retinal prostheses for the blind are in clinical trials worldwide, including the FDA-approved Argus II prosthesis. Each retinal prosthesis attempts to position stimulus electrode arrays in close proximity to the retina in order to effectively activate the remaining retinal neural circuitry. Retinal activation by electrodes in different locations on the retinal surface are not all equivalent. Stimulus pulses can be markedly attenuated by resistive and capacitive barriers in the eyewall, which in some cases could prevent effective activation of the retinal tissue. Here we plan to investigate the impedance correlates of mechanical damage to the inner retina by the stimulus electrodes, as well as electrically-mediated damage (due to high charge density). The main objective of this project is to determine safety throughout the period when the implant is used, in situ, leveraging currently available technology for retinal implants. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93533
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Nathalia Peixoto. NSF/FDA SIR: Bioimpedance of stimulating electrodes for the safe placement of retinal implants. 2014-01-01.
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