| 项目编号: | 1512755
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| 项目名称: | UNS:Integrating nanoparticle design and in vivo testing to proactively reduce environmental impacts |
| 作者: | Robert Tanguay
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| 承担单位: | Oregon State University
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| 批准年: | 2014
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| 开始日期: | 2015-09-01
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| 结束日期: | 2018-08-31
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| 资助金额: | USD300000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | environmental impactspi
; biocompatibility
; advance material design
; nanoparticle design
; molecular-level design
; basic design principle
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| 英文摘要: | Title: Integrating nanoparticle design and in vivo testing to proactively reduce environmental impacts
PI: Tanguay, Robert L. and Hutchison, James E.
Institution: Oregon State University and the University of Oregon
There has been progress in recent years in developing basic design principles for safer nanoparticles (NPs). Although we now understand that material composition plays an important role in governing the toxicity of some materials, there is increased awareness that surface properties are particularly important when considering biocompatibility. It remains unclear how the identity of the functional groups and ligand density influence toxicity. This project will systematically explore the role of adjusting the composition, diversity and density of ligand shells in governing biocompatibility. The impact of the proposed work will be many fold. First, the products of the research will enable researchers to employ the discovered guidelines for molecular-level design as a foundation to advance materials design. The precision libraries will serve as new reference materials for the nanoEHS research community, thereby leveraging the activities of basic and applied researchers across disciplines. Society will benefit from the reduction in negative consequences of future products on health and the environment. Finally, the research team will use the integrated nature of this project to provide undergraduate and graduate students with a dynamic multidisciplinary educational experience. The co-PIs and students will communicate not only with colleagues, but also with members of the broader public. The latter goal will be achieved via hands-on and online demonstrations targeting K-12 audiences.
The PIs will develop precision engineered NP libraries that are designed specifically to define the importance of the NP surface on biocompatibility. To improve the relevance and sensitivity of biocompatibility measures, they will use the high throughput multi-dimensional embryonic zebrafish system. Determining the relationship between avidity and toxicity will inform the use of the mixtures of ligands likely to appear in next generation applications. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93612
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Robert Tanguay. UNS:Integrating nanoparticle design and in vivo testing to proactively reduce environmental impacts. 2014-01-01.
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