| 项目编号: | 1546589
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| 项目名称: | EAGER: Chiral Membranes for Protein Resistance |
| 作者: | Georges Belfort
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| 承担单位: | Rensselaer Polytechnic Institute
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| 批准年: | 2014
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| 开始日期: | 2015-08-15
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| 结束日期: | 2017-07-31
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| 资助金额: | USD180000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | protein fouling
; protein
; chiral hypothesis
; membrane surface chirality
; protein solution
; chiral surface
; 1546589rpibelfortthis eager proposal
; protein resistance
; non-specific protein-membrane surface interaction
; chiral membrane
; non-specific protein adhesion
; same chirality
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| 英文摘要: | 1546589
RPI
Belfort
This EAGER proposal is potentially a high risk high payoff effort as it involves a transformative, new approach to reduce non-specific protein-membrane surface interactions. Recently the PI discovered that membrane surface chirality influences filtration with protein solutions. A molecule is considered chiral if there exists another molecule that is of identical composition, but which is arranged in a non-superposable mirror image, i.e. similar to human hands. Non-specific protein adhesion or protein fouling occurs with synthetic membrane filtration in bioprocessing, with marine structures and with medical devices. This undesired adhesion of proteins is a major technical and economic challenge. Reducing these limitations with chiral surfaces would be significant and have broad impact.
The PI proposes that the surface should have the same chirality as a protein (the chiral hypothesis). The goals of the research are to (i) confirm, expand and investigate the role of chirality with respect to protein resistance, and (ii) determine if chiral membranes can fractionate enantiomers for small molecules. This radically different approach to possibly reducing protein fouling is in its early stages and is potentially transformative for bioprocessing. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93686
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Georges Belfort. EAGER: Chiral Membranes for Protein Resistance. 2014-01-01.
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