| 项目编号: | 1451903
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| 项目名称: | EAGER: Integration of Conducting Polymers With Living Cells |
| 作者: | Christine Payne
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| 承担单位: | Georgia Tech Research Corporation
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| 批准年: | 2014
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| 开始日期: | 2015-08-01
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| 结束日期: | 2017-07-31
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| 资助金额: | USD60061
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cell
; polymer
; polymer-cell
; polymer nanowire
; electrochemical polymerization
; aim
; individual cell
; intracellular delivery
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| 英文摘要: | PI: Payne, Christine K.
Proposal Number: 1451903
Advances in neuroscience and neuroengineering require new tools. Of specific need is the ability to interface electrical devices with the brain. The challenge is coupling hard metal surfaces to the soft environment of the brain. To address this problem, the investigators will pursue a novel direction, using soft, flexible, biocompatible conducting polymers to form nanowires within individual cells. These conducting polymer nanowires will provide a new tool for neural probes, bionic implants, regenerative medicine, and the treatment of neurological disorders.
This research will address two specific goals; intracellular delivery of a foreign material into cells and electrochemical polymerization in a protein-rich, high salt, environment. Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) will be used as a representative conducting polymer. Aim 1 will focus on delivery of the monomer into the cell using the cell's own pinocytic machinery. Experiments will use PC-12 model neurons. Aim 2 will electrochemically polymerize the monomer to form a nanowire within the cell, establishing contacts between external electrodes and the cell. Each Aim is accompanied by extensive cytotoxicity assays to ensure the cells remain healthy during the process. In addition to the biomedical applications enabled by a hybrid conducting polymer-cell, this research will provide interdisciplinary training at the interface of engineering and life sciences for a diverse group of students at the high school, undergraduate, and graduate level. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/93831
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Christine Payne. EAGER: Integration of Conducting Polymers With Living Cells. 2014-01-01.
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