| 项目编号: | 1512250
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| 项目名称: | SusChEM:Characterization of oxidative stress response to improve microalgae-based biofuel production in wastewater |
| 作者: | Annaliese Franz
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| 承担单位: | University of California-Davis
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| 批准年: | 2014
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| 开始日期: | 2015-07-15
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| 结束日期: | 2018-06-30
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| 资助金额: | USD309813
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | oxidative stress response
; wastewater
; lipid production
; microalgae
; oxidative stress tolerance
; waste water
; algal biofuel production
; lipid
; dairy wastewater
; algal biofuel production process
; wastewater remediation
; coupling biofuel production
; oxidative stress
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| 英文摘要: | PI: Annaliese Franz
Proposal Number: 1512250
Microalgae are single-celled photosynthetic organisms that grow on atmospheric carbon dioxide, sunlight, and dissolved mineral nutrients. Under the proper conditions, microalgae also produce fatty acids stored as lipids, which can be readily converted to biofuel such as biodiesel. To reduce the costs of algal biofuel production processes and at the same time improve sustainable reuse of water, algae can be grown on dissolved mineral nutrients in various types of waste water. However, the use of waste water as nutrient source may put stress on the growth and metabolism of the organism. This project will study the possible link between oxidative stress and lipid production in industrially-relevant strains of microalgae using techniques of molecular biology. The outcomes of the research may suggest ways to minimally treat waste water to make it more amenable for use in algal biofuel production. The educational aspects of this project focus on mentoring middle school girls to stimulate their interest in science and engineering using bioenergy modules developed for this purpose.
The overall goal of this research is to characterize oxidative stress response and regulation of gene expression in industrially-relevant microalgae strains in order to identify improved conditions for coupling biofuel production with wastewater remediation. The overall approach is to correlate relevant phenotypes with metabolomic and transcriptomic studies for lipid producing strains of microalgae to understand global metabolism and lipid pathway changes under conditions that promote oxidative stress response, including kinetic and concentration effects of treated cultures with a primary focus on algae cultivation in wastewater. High lipid producing strains (P. tricornutum, C. sorokiniana and N. salina) will be selected for study based on their industrial and scientific relevance as well as availability of genomic information. The research plan has three objectives. The first objective is to characterize oxidative stress response and regulation of gene expression in lipid producing microalgae, including kinetic and concentration effects for two scenarios - peroxide-induced lipid accumulation and cultivation on dairy wastewater. The second objective is to evaluate application of antioxidants to improve oxidative stress tolerance in high-oil-producing microalgae. Finally, the third objective is to evaluate effect of peroxide- and antioxidant treatment as variables to improve biomass and lipid production of microalgae cultured in wastewater. The education and outreach activities of this project focus on bioenergy topics, and are designed to broaden participation of women and under-represented students in STEM through existing programs at the University of California at Davis, particularly for middle school girls. A bioenergy module focusing on renewable energy and environmental sustainability will be developed to help deliver these education and outreach programs. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94023
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Annaliese Franz. SusChEM:Characterization of oxidative stress response to improve microalgae-based biofuel production in wastewater. 2014-01-01.
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