| 项目编号: | 1512826
|
| 项目名称: | UNS:Optogenetic Control of Neuronal Activity With Activity-Dependent Bioluminescence |
| 作者: | Ken Berglund
|
| 承担单位: | Emory University
|
| 批准年: | 2014
|
| 开始日期: | 2015-07-15
|
| 结束日期: | 2018-06-30
|
| 资助金额: | USD549641
|
| 资助来源: | US-NSF
|
| 项目类别: | Standard Grant
|
| 国家: | US
|
| 语种: | 英语
|
| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
|
| 英文关键词: | neuronal activity
; neural activity
; abstractoptogenetic control
; novel optogenetic probe
; optogenetic activation
; activity-dependent expression
; spatiotemporal control
|
| 英文摘要: | Abstract
Optogenetic control of neuronal activity has become a driving force in neuroscience research but its clinical application has been limited due to the fact that delivery of physical light into the brain poses a technical burden. This proposal aims to develop novel optogenetic probes that can report neuronal activity in a non-invasive manner and provide neuromodulation throughout the brain.
This project will develop layers of spatiotemporal control over optogenetic activation by a diffusible chemical (drug) in combination with activity-dependent expression and activation. Neuromodulation will be delivered to neurons autonomously only when and where it is needed. These new reagents will offer two new versatile methods of probing neural circuitry in a noninvasive manner: optically reporting neural activity via bioluminescence and perturbing neural circuitry in a closed-loop fashion. This will be particularly important for conducting long term invivo studies and future clinical translation. |
| 资源类型: | 项目
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94039
|
| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
|
|
There are no files associated with this item.
|
| Recommended Citation: | |
Ken Berglund. UNS:Optogenetic Control of Neuronal Activity With Activity-Dependent Bioluminescence. 2014-01-01.
|
|
|