| 项目编号: | 1511353
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| 项目名称: | UNS: All-Optical Interrogation System for Cardiac Dynamics |
| 作者: | Emilia Entcheva
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| 承担单位: | SUNY at Stony Brook
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| 批准年: | 2014
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| 开始日期: | 2015-07-01
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| 结束日期: | 2016-01-31
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| 资助金额: | USD328622
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | biological function
; space-time
; cardiac dynamics
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| 英文摘要: | PI: Entcheva, Emilia
Proposal: 1511353
The PI will develop and validate a new dynamic space-time resolved all-optical approach to cardiac dynamics. The unique advantages of optogenetic actuation will be combined with simultaneous high-resolution optical imaging to offer a conceptually new way of quantifying cardiac instabilities and predict arrhythmias.
They will demonstrate a general framework for contactless probing of biological function in space-time by optogenetic means that can be applied not only to perturbing and observing membrane potential in excitable cells, but also for the study of cell signaling, gene expression, for which optogenetic tools exist. The all-optical methodology allows for straightforward integration of real-time feedback control in vitro and in vivo, which can yield new insights into biological function and ability to control it. To broaden the educational impact of the proposed work, the PI, a dedicated mentor of early-stage trainees, will: 1) collaborate with the BioPREP program at Stony Brook to recruit academically-strong community college students from underprivileged background, helping them pursue a career in STEM; and 2) will integrate the developed techniques into a new formal course on quantitative optogenetic approaches to the study of biological functions, which will be offered not only at Stony Brook in a regular format, but also online via the Coursera educational platform. The evaluation of educational outcomes will be done by tracking of the career paths of trained students via social media. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94263
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Emilia Entcheva. UNS: All-Optical Interrogation System for Cardiac Dynamics. 2014-01-01.
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