| 项目编号: | 1512598
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| 项目名称: | UNS:ADVANCING CELL-PRESERVING SEPARATION VIA DETACHABLE CELL ANCHORING & SPIRAL MICRO-MIXING |
| 作者: | Princess Imoukhuede
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| 承担单位: | University of Illinois at Urbana-Champaign
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| 批准年: | 2014
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| 开始日期: | 2015-07-01
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| 结束日期: | 2018-06-30
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| 资助金额: | USD371845
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cell
; cell separation
; capture cell
; different tumor cell type
; endothelial cell
; cell release
; immune cell
; tumor cell
; cell-anchoring
; detachable cell-anchoring
; spiral micro-mixing
; microfluidic platform
; spiral micro-mixer design parameter
; cell anchoring
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| 英文摘要: | 1512598
Imoukhuede
Uof Ill Urbana-Champaign
Cell separation is especially necessary to advance personalized cancer medicine, because tumors contain a diverse mix of cells with different biomarkers that makes them difficult to treat. If different tumor cell types can be separated and analyzed the promise of tailoring drugs to the unique characteristics of a patient's tumor may be analyzed. The proposed research aims to engineer a fast and gentle cell separation system on a microscale.
The ability to capture cells onto a surface and release by targeting a secondary moiety within the anchor would enable gentler, cell separation. As such, the proposed research aims to combine spiral micro-mixing with cell anchoring and secondary moiety targeted cell release to enable a cell separation from blood that is also receptor-preserving. The specific research goals are as follows: (1) identify the optimum conditions for detachable cell-anchoring; (2) determine the spiral micro-mixer design parameters enabling detachable cell-anchoring; (3) develop the microfluidic platform that will separate circulating endothelial cells, immune cells, and tumor cells from blood samples while preserving surface receptors on isolated cells. The proposed work may develop innovative technology that advances science while championing a high-impact, educational mission. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94312
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Princess Imoukhuede. UNS:ADVANCING CELL-PRESERVING SEPARATION VIA DETACHABLE CELL ANCHORING & SPIRAL MICRO-MIXING. 2014-01-01.
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