| 项目编号: | 1509218
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| 项目名称: | UNS:Erythrocyte-derived optical nano-vesicles as photo-theranostic agents |
| 作者: | Bahman Anvari
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| 承担单位: | University of California-Riverside
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| 批准年: | 2014
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| 开始日期: | 2015-06-15
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| 结束日期: | 2018-05-31
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| 资助金额: | USD355759
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | nanoparticle
; engineer nanoparticle
; theranostic agent
; work
; tumor
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| 英文摘要: | PI: Anvari, Bahman
Proposal No.: 1509218
The unique contribution of this proposed work is the ability to engineer nanoparticles that can be made using the patient's own erythrocytes to extend the circulation time and minimize biocompatibility issues so that these nanoparticles can interact with tumors. Light energy can then be used with the nanoparticles to generate heat and provide localized hyperthermia at the tumor to destroy it or augment chemo or radiotherapy. Personalized medicine has great potential and this work can make important contributions to this field.
Effective treatment with a minimum of side effects of various malignant tumors remains an important problem in modern medicine. Personalized medicine gives the opportunity to direct and optimize such treatment to individual patients based upon their genetic and immunological makeup. This proposal will develop ghost erythrocytes loaded with fluorescent dyes as theranostic agents to image cancer cells by fluorescence and also to induce photothermal killing damage. The erythrocytes will be functionalized with an antibody to target tumors in vivo in xenograft mouse models. The PI has had many under-represented students in his lab. Aspects of the work will be incorporated into a new class. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94408
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Bahman Anvari. UNS:Erythrocyte-derived optical nano-vesicles as photo-theranostic agents. 2014-01-01.
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