| 项目编号: | 1501554
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| 项目名称: | DISSERTATION RESEARCH: Genomic signatures of pathogen-mediated selection in diachronic populations of the House Finch |
| 作者: | John Wakeley
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| 承担单位: | Harvard University
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| 批准年: | 2014
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| 开始日期: | 2015-06-01
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| 结束日期: | 2017-05-31
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| 资助金额: | USD21940
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | house finch
; pathogen
; resistance
; strong selection
; unexposed population
; wild population
; eastern population
; tolerance
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| 英文摘要: | This study will examine how the House Finch has evolved resistance and tolerance to a novel pathogen. Novel pathogens are a challenge faced by many species, and understanding how species might respond is integral for informing conservation efforts to protect global biodiversity. Human-mediated introductions of pathogens into new environments are common today given the ease of global travel. In 1994, a species of bacteria, Mycoplamsa gallisepticum, historically associated with poultry, infected the House Finch and killed an estimated 225 million individuals (60% of the eastern population). This pathogen is the cause of one of the most significant diseases of the poultry industry, so any genes identified as targets of evolution in this House Finchmay also be applicable to improving resistance and tolerance in poultry.
The project will use whole genome resequencing and genotyping of immune genes such as MHC and TLRs to disentangle the genetic underpinnings of two important immunological responses, resistance and tolerance. Data collected from wild populations around the U.S. in multiple time periods before and after exposure to the pathogen will show how the House Finch has evolved. The researchers will test whether MHC and TLR intra-individual allelic diversity has increased in response to strong selection, or if specific alleles confer resistance or susceptibility to the pathogen by increasing or decreasing in frequency over time. Genotyping of experimentally infected individuals from a historically unexposed population will test whether putatively selected alleles are associated with disease phenotypes such as pathogen load or conjunctival swelling. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94495
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
John Wakeley. DISSERTATION RESEARCH: Genomic signatures of pathogen-mediated selection in diachronic populations of the House Finch. 2014-01-01.
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