| 项目编号: | 1515734
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| 项目名称: | RAPID: Understanding and leveraging asymptomatic infections to control Ebola virus transmission |
| 作者: | Juliet Pulliam
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| 承担单位: | University of Florida
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| 批准年: | 2014
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| 开始日期: | 2015-06-01
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| 结束日期: | 2016-12-31
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| 资助金额: | USD133213
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | asymptomatic infection
; ebola virus
; previous ebola epidemic
; ebola outbreak
; protective immunity
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| 英文摘要: | This research will develop a mathematical model to understand the role of asymptomatic infections and protective immunity on the spread of Ebola virus. Based on their previous research the investigators have shown that 20-60% of people exposed to Ebola virus never develop clinical disease and remain asymptomatic. It is unclear if a person who is asymptomatically infected gains protective immunity against future exposure to the Ebola virus. If asymptomatic infections do offer protection, this could be extremely important in understanding and reducing the spread of Ebola virus. As part of the project, the investigators will develop and share easy-to-use, open access modeling tools that can be utilized by the public health policy and research community.
The research team proposes five specific aims in modeling and understanding asymptomatic infections. They will design and study public health interventions that could leverage the effects of this protective immunity. One such strategy would include modeling a potential workforce comprised of caregivers who have been asymptomatically infected to establish a viral barrier similar to a ring vaccination strategy. They will characterize the implications of asymptomatic infections for vaccine trial design. They will utilize latent process models to determine if asymptomatic infections contributed to the scope and decline of previous Ebola epidemics, looking to see if there is a signature of asymptomatic immunity within an Ebola outbreak. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/94556
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Juliet Pulliam. RAPID: Understanding and leveraging asymptomatic infections to control Ebola virus transmission. 2014-01-01.
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