| 项目编号: | 1454365
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| 项目名称: | CAREER: Structure-Functional Imaging of the Atrial Myocardium |
| 作者: | Christine Hendon
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| 承担单位: | Columbia University
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| 批准年: | 2014
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| 开始日期: | 2015-03-01
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| 结束日期: | 2020-02-29
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| 资助金额: | USD500000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | atrial fibrillation
; optical imaging system
; tissue functionality
; functional electrical analysis
; pi
; healthy myocardium
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| 英文摘要: | PI: Hendon, Christine
Proposal: 1454365
Atrial fibrillation (AF), the most common type of arrhythmia, is characterized by quivering of the atria due to unorganized electrical activity. Those with AF run the risk of stroke due to blood clots developed in the atria or heart failure from lack of pumped blood. This proposal focuses on improving ablation techniques used to treat atrial fibrillation through the addition of optical imaging systems. If successful, this would be the first real time imaging tool capable of assisting in this very common surgical procedure. The Educational Plan emphasizes activities designed to recruit more women and minority students into graduate level engineering program. The PIs will integrate this platform into their signal processing and instrumentation courses.
The proposal focuses on improving ablation techniques used to treat atrial fibrillation through the addition of an optical imaging system using Optical Coherence Tomography (OCT) and near infrared spectroscopy (NIRS) to characterize fiber orientation and tissue composition, measure ablation depth, and determine if such information, along with functional electrical analysis, can be used to produce more efficacious lesions, i.e., ones that are not unnecessarily large or do not have to be redone. The PI will bring her expertise in optics and signal processing to bear on assessing therapy of atrial fibrillation using radiofrequency ablation. Using NIRS should provide a highly useful method for assessing RFA lesions. Preliminary data confirm that polarization sensitive OCT can detect fiber orientation, a key physiological parameter in assessing tissue functionality. The results show good potential for distinguishing healthy myocardium from fibrotic tissue.
This award is co-funded by the Biophotonics program (CBET) in the Engineering Directorate and the Communications, Circuits, & Sensing Systems (ECCS) in the Engineering Directorate. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95030
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Christine Hendon. CAREER: Structure-Functional Imaging of the Atrial Myocardium. 2014-01-01.
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