| 项目编号: | 1453538
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| 项目名称: | CAREER:Exploring Structure-Function Relationships in the Human Airways Through Fluid Mechanics Experiments |
| 作者: | Filippo Coletti
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| 承担单位: | University of Minnesota-Twin Cities
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| 批准年: | 2014
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| 开始日期: | 2015-02-01
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| 结束日期: | 2020-01-31
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| 资助金额: | USD509559
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | diseased human airway
; experimental system
; fluid mechanic
; human airway
; fluid structure interaction
; functional implant
; career project
; significant bio-inspired fluid dynamics problem
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| 英文摘要: | 1453538
Coletti
The main goal of this CAREER project is to explore how structural features of healthy and diseased airways affect the fluid mechanics of respiration. Since currently used aerosol drug delivery techniques are not efficient, the proposed work would have an impact on targeted drug delivery for respiratory diseases. It could also improve the design and manufacturing of functional implants. The proposed study of both healthy and diseased human airways can offer an understanding of the effect of behaviors such as smoking on the fluid structure interactions of airways. 3D printing of realistic airways significantly increases the broader impact of this research, because it offers a more direct connection to actual airways, and how they are changed by disease. The inclusion of particle deposition is also important because of its potential impact on inhalation therapies. The proposed educational activities combine engineering, physiology, and advanced imaging, such as the development of a 3D printed virtual tour of the lung based on MRI imaging as outreach to the public.
The PI proposes to address a rather significant bio-inspired fluid dynamics problem with an arsenal of state-of-the-art tools: MRI imaging and PIV velocimetry to characterize the flow experimentally and 3D printing for fabricating models to study realistic geometries for healthy and diseased human airways. The experimental system has already been manufactured so that important dimensionless groups in the model are matched to actual behavior in the human airways. The PI proposes to explore the relation between structure, defined as the morphology and the mechanical properties of the airways, and function, defined as the transport of inhaled particles. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95143
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Filippo Coletti. CAREER:Exploring Structure-Function Relationships in the Human Airways Through Fluid Mechanics Experiments. 2014-01-01.
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