| 项目编号: | 1445727
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| 项目名称: | NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices |
| 作者: | Roger Narayan
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| 承担单位: | North Carolina State University
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| 批准年: | 2013
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| 开始日期: | 2014-11-01
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| 结束日期: | 2017-10-31
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| 资助金额: | USD130000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | program
; small-scale
; scholar-in-residence
; sub-micrometer scale
; incorporation
; material property-biological performance database
; riboflavin-triethanolamine mixture
; technical descriptionin
; creatinine sensor material
; biocompatible photoinitiator
; microscale feature
; in vitro biological characterization
; fundamental tissue-material interaction
; 3d printing technique
; cell-material interaction
; riboflavin-arginine mixture
; innovative device technology
; 3d printed small-scale medical devicessignificancethe datum
; photon polymerization-based 3d printing
; sub-microscale feature
; cell ingrowth
; protein adsorption
; nsf/fda scholar
; residence program
; epidermal keratinocyte
; material processing parameter
; innovative small-scale device
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| 英文摘要: | PI: Narayan, Roger J.
Proposal: 1445727
Title: NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices
Significance
The data obtained in this project will serve as the basis for a material property-biological performance database, in which the relationship between in vitro cell-material interactions, protein adsorption, and material processing parameters will be considered. The regulatory science approach will provide a repertoire of methods and tools to understand the fundamental tissue-material interactions for complex and innovative device technologies.
Technical Description
In the proposed Scholar-in-Residence (SIR) program, a 3D printing technique known as multi-focus two photon polymerization will be used to create solid tissue barb adhesives with microscale features for tissue penetration and sub-microscale features for cell ingrowth out of a zirconium oxide hybrid material. Tissue barbs are innovative small-scale devices with potential use in wound closure and healing. They will examine use of biocompatible photoinitiators (e.g., riboflavin-triethanolamine mixtures and riboflavin-arginine mixtures) for two photon polymerization-based 3D printing. They will also evaluate incorporation of an electrochemical sensor for monitoring of creatinine within the tissue barb adhesive. In the proposed program, they will collaborate with FDA colleagues to evaluate the in vitro biocompatibility of tissue barb materials that contain sub-micrometer scale pores and creatinine sensor materials using appropriate cells (e.g., dermal fibroblasts and epidermal keratinocytes). |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95382
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Roger Narayan. NSF/FDA Scholar in Residence Program on In Vitro Biological Characterization of 3D Printed Small-Scale Medical Devices. 2013-01-01.
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