| 项目编号: | 1437831
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| 项目名称: | Collaborative Research: Dynamics and Self-Assembly in Block Copolymer Micelles for Tailored Cargo Delivery |
| 作者: | Megan Robertson
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| 承担单位: | University of Houston
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| 批准年: | 2013
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| 开始日期: | 2014-09-01
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| 结束日期: | 2018-02-28
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| 资助金额: | USD165067
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | block copolymer
; dynamics
; block copolymer micelle
; tiny self-assembled capsule
; micelle
; detailed solvent dynamics
; polymer chain
; collaborative project
; cbet 1437831/1437767micelles
; micelle dynamics
; drug delivery
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| 英文摘要: | CBET 1437831/1437767
Micelles are tiny self-assembled capsules that can be customized for a variety of technological applications, including carrying drug molecules to a specific location inside the body as well as cleaning up environmental spills. Micelles can be composed of molecules made of two kinds of linked polymer chains, called block copolymers. Micelle behaviors can be finely tuned by changing the molecular structure of the block copolymers, and thus purposely designing the uptake amounts and release rates of interior compounds (such as drugs). This collaborative project explores the structure of block copolymer micelles as well as the block copolymer motions. By combining advanced analysis methods, the investigators will determine how the micelle-encapsulated compounds affect micelle structure and motions, and the exchange of compounds between micelles and their surroundings. This information will help scientists and engineers precisely formulate micelles for new applications in drug delivery, advanced lubrication, oil extraction, personal care products and other industries.
This project aims to systematically examine the effects of small molecule additives, co-solvents, and encapsulated drug molecules, on the structure and dynamics of block copolymer micelles. Targeted model additives (tetrahydrofuran and doxorubicin) will be employed to uncover the influence of such additives on micelle structure and dynamics. Small angle neutron scattering and multi-modal nuclear magnetic resonance will be used to investigate the effects of additive-polymer interactions on micelle equilibrium structure, polymer chain and micelle dynamics, and release rates of encapsulated compounds. The combination of these techniques will provide a comprehensive picture of key micellar dimensions and highly specific dynamical information including free unimer exchange kinetics, block and polymer chain dynamics, micelle diffusion processes, detailed solvent dynamics and exchange of additives in and out of micelles, and rates of fission and fusion. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95601
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Megan Robertson. Collaborative Research: Dynamics and Self-Assembly in Block Copolymer Micelles for Tailored Cargo Delivery. 2013-01-01.
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