| 项目编号: | 1450187
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| 项目名称: | EAGER: Extending cell phone capabilities for sensitive detection in lateral flow assays |
| 作者: | Paul Yager
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| 承担单位: | University of Washington
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| 批准年: | 2013
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| 开始日期: | 2014-09-01
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| 结束日期: | 2017-08-31
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| 资助金额: | USD299776
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | smart phone
; lateral flow format
; cell phone capability
; lateral flow strip detection zone
; useful chemical detection
; current lateral flow device
; next-generation phone
; acoustic detection
; detection process
; conventional lateral flow-based assay
; sensitive detection
; nucleic acid detection test
; additional capability
; detection sensitivity
; pi
; lateral flow assayssignificance
; cellular telephone
; detection line
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| 英文摘要: | PI: Yager, Paul
Proposal: 1450187
Title: EAGER: Extending cell phone capabilities for sensitive detection in lateral flow assays
Significance:
Decentralization of today's most sophisticated biochemical measurements has the potential to revolutionize many fields, from medicine to agriculture; there is great potential to reduce societal costs, improve outcomes by more frequent measurements, and make field measurements that are currently impossible. One promising decentralization approach is to couple new inexpensive disposable chemical devices with our smart phones, which provide "free" measurement and analysis capacity, and can immediately transmit data anywhere. In all such measurement, the sensitivity of the detection process determines whether the measurement is useful. Current lateral flow devices (e.g., home pregnancy tests) are rapid, robust, inexpensive, and useful, but the few commercial systems detect a small set of relatively concentrated analytes. To successfully use antibody binding or nucleic acid detection tests for lower-abundance analytes, we need a significant increase in detection sensitivity. The proposed new methods for detecting analytes in this project could bring such capacity to the lateral flow format. The aim is to minimize cost and maximize speed of adoption by implementing these methods so that they can be carried out with current or next-generation smart phones.
Intellectual Description:
A goal of this work is to determine whether a particular set of additional capabilities associated with cellular telephones would add significant functionality for smart phones with respect to biochemical measurement, specifically to improving the sensitivity of current and conventional lateral flow-based assays. The PI proposes ways in which next-generation phones could enhance our ability to do useful chemical detection anywhere, whether for medicine, environmental monitoring, process monitoring, laboratory science or education.
The PI will utilize acoustic detection of rapid heating of the detection lines to measure the amplitude of binding. This approach is used in photoacoustic ultrasound imaging, in which the lateral flow strip detection zone is illuminated by a rapid flash of light. Alternatively, one could raster scan a bright light beam as is done in today?s commercial barcode scanners |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95751
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Paul Yager. EAGER: Extending cell phone capabilities for sensitive detection in lateral flow assays. 2013-01-01.
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