| 项目编号: | 1403228
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| 项目名称: | Collaborative Research: Sense-and-Act Systems for Substance Release Modeling Drug Delivery Triggered by Immune-Sensing Based on Nanostructured Electrodes |
| 作者: | Luis Martinez-Lemus
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| 承担单位: | University of Missouri-Columbia
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| 批准年: | 2013
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| 开始日期: | 2014-08-15
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| 结束日期: | 2018-07-31
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| 资助金额: | USD49569
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | drug-release
; sense-and-act
; immune-sensing
; drug release
; drug-release system
; drug administration
; signal-triggered substance-releasing system
; collaborative research
; nanostructured electrodesthis research program
; electrochemical release process
; nanostructured biosensing system
; projectthis research program address key challenge
; signal-triggered release
; biomolecular substance
; active biomolecule
; insulin release
; immunesensing assembly
; nanostructured electrode
; sense-and-act systems
; redox non-active low-molecular-weight substance
; substance release modeling drug delivery
; self-activated drug-release system
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| 英文摘要: | Proposal: 1403208/1403228
PI: Katz, Evgeny/Martinez-Lemus, Luis
Institution: Clarkson University/University of Missouri, Columbia
Title: Collaborative Research: Sense-and-Act Systems for Substance Release Modeling Drug Delivery Triggered by Immune-Sensing Based on Nanostructured Electrodes
This research program combines a nanostructured biosensing system with a drug-release system. The transformative nature of this work is in the novel concept of integrating the electrochemical sensing and electrochemical release processes, promising revolutionary changes in personalized drug administration, particularly in emergency situations and in point-of-care and end-user applications. Specifically, the program aims at designing new systems for detecting critical conditions associated with diabetes, with the detection followed by automated drug release to compensate for the medical problem. The research is initially carried out with model systems, but will culminate in animal study.
Technical description of the project
This research program address key challenges to developing bioelectronic systems for sensing non-electrochemically active biomolecules, e.g., proteins, as well as redox non-active low-molecular-weight substances. The sensing process is integrated with the actuation resulting in the signal-triggered release of biomolecular substances mimicking drug-release, for example, Insulin release triggered by ketone bodies that are biomarkers of ketoacidosis. The developed bioelectronic systems integrate parts characteristic of biosensing/immunesensing systems, biofuel cells and signal-triggered substance-releasing systems, thus representing a unique combination of components for autonomous self-powered operation. Specifically, model systems of increasing complexity are developed that can yield negative potential at a nanostructured electrode by utilizing attached enzymes and immunesensing assemblies, in response to antigens. The resulting potential suffices for activation, on another part of the connected electrode system, of the process of dissolution of an alginate layer in which the molecules mimicking drug are entrapped, triggering drug release. Such self-powered and self-activated drug-release systems operating in response to biomarker sensing represent novel approach to the ?Sense-and-Act? systems. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/95992
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Luis Martinez-Lemus. Collaborative Research: Sense-and-Act Systems for Substance Release Modeling Drug Delivery Triggered by Immune-Sensing Based on Nanostructured Electrodes. 2013-01-01.
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