| 项目编号: | 1505412
|
| 项目名称: | CAREER: "Holey Scaffold" Sensing System for Characterization of the Spatiotemporal Tumor Response to Nanoparticle-Mediated Photothermal and Photochemical Therapy |
| 作者: | Nichole Rylander
|
| 承担单位: | University of Texas at Austin
|
| 批准年: | 2013
|
| 开始日期: | 2014-08-10
|
| 结束日期: | 2016-09-30
|
| 资助金额: | USD279407
|
| 资助来源: | US-NSF
|
| 项目类别: | Standard Grant
|
| 国家: | US
|
| 语种: | 英语
|
| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
|
| 英文关键词: | holey scaffold
; tumor response
; nanoparticle-mediated laser therapy
; nanoparticle-mediated
; nanoparticle
; career plan
; spatiotemporal nanoparticle transport
; career objective
; real-time photochemical response
; bioreactor system
; biochemical response
; scaffold framework
; dynamic photothermal response
; laser therapy
; dynamic nanoparticle transport
; mouse tumor model
; nanoparticle property
; simultaneous optical sensing/imaging
|
| 英文摘要: | 0955072
Rylander
The goal of this CAREER plan is to create and utilize a novel sensing system called the "holey scaffold" to nondestructively and minimally invasively measure dynamic nanoparticle transport and photothermal and photochemical tumor response to nanoparticle-mediated laser therapy. A holey scaffold is a new technology co-invented by the PI that is composed of an embedded network of microchannels within a scaffold framework upon which cells and tissues can be grown. Hollow core fibers integrated in the holey scaffold permit simultaneous optical sensing/imaging of dynamic processes and selective delivery of biological agents (e.g. nutrients, cells, nanoparticles) for control of biochemical responses. The CAREER objective is to use holey scaffolds to measure 1) spatiotemporal nanoparticle transport for varying nanoparticle properties, targeting approaches, and delivery methods, 2) dynamic photothermal response (temperature, heat shock protein expression, and cell injury), and 3) real-time photochemical response (reactive oxygen species production) associated with nanoparticle-mediated laser therapies. The versatility of holey scaffolds will enable the first measurement of dynamic tumor response in vitro within a bioreactor system and in vivo in a mouse tumor model. Measured tumor response will be utilized to create a novel computational model for predicting tumor response and optimizing implementation of nanoparticles in laser therapy. |
| 资源类型: | 项目
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96046
|
| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
|
|
There are no files associated with this item.
|
| Recommended Citation: | |
Nichole Rylander. CAREER: "Holey Scaffold" Sensing System for Characterization of the Spatiotemporal Tumor Response to Nanoparticle-Mediated Photothermal and Photochemical Therapy. 2013-01-01.
|
|
|