| 项目编号: | 1406805
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| 项目名称: | DISSERTATION RESEARCH: The Genetic Architecture of Covarying Traits |
| 作者: | Thomas Mitchell-Olds
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| 承担单位: | Duke University
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| 批准年: | 2013
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| 开始日期: | 2014-08-01
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| 结束日期: | 2017-07-31
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| 资助金额: | USD20366
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | trait
; multiple trait
; genetic covariance
; glucosinolate trait
; trait correlation
; genetic basis
; genetic architecture
; genetic variation
; evolutionary genetics
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| 英文摘要: | The capacity of organisms to respond to selective pressures on multiple traits is determined in part by the genetic covariances between those traits. This project will map regions of the genome associated with genetic variation in glucosinolate traits in a population of Boechera stricta, a model plant for evolutionary genetics. B. stricta makes several types of glucosinolates, compounds that defend the plant against insect herbivores. By mapping the regions of the genome that control glucosinolate profile in each type of plant tissue, the investigator will determine whether the same or different loci control glucosinolates throughout the plant. Then, using population data at these genomic regions, the amount of covariation in glucosinolate traits controlled by each locus will be determined.
Knowing the genetic architecture of covarying traits is essential in predicting how those traits are able to respond to selection; if one gene controls multiple traits, evolutionary constraints are likely to be stronger than if trait correlations are caused by correlated selective pressures. Genetic covariances have been important to plant breeders, as well, as they may affect the response to artificial selection. Understanding the genetic basis of glucosinolate allocation, which is agriculturally relevant and affects cancer risk in humans, will lend insight into how breeding programs may affect crop plants. This grant will also support training of a young scientist in important genomic techniques and analyses, as well as outreach efforts in traditionally underperforming schools encouraging students, particularly girls, to pursue college and a career in the STEM fields. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96198
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Thomas Mitchell-Olds. DISSERTATION RESEARCH: The Genetic Architecture of Covarying Traits. 2013-01-01.
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