| 项目编号: | 1445488
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| 项目名称: | EAGER: Bio-Inspired Nanostructured Microsensor Arrays for Selective Chemical Sensing |
| 作者: | Karolyn Hansen
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| 承担单位: | University of Dayton
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| 批准年: | 2013
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| 开始日期: | 2014-08-01
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| 结束日期: | 2018-02-28
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| 资助金额: | USD157125
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | bio-inspiration
; fabrication
; odorant receptor protein
; high surface area
; new biosensor
; nanostructured surface
; detection
; bio-inspired nanostructured microsensor arrays
; biological olfactory system
; selective chemical sensingorganisms
; micromechanical nanostructured sensor
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| 英文摘要: | Proposal: 1445488
PI: Hansen, Karolyn M.
Title: EAGER: Bio-Inspired Nanostructured Microsensor Arrays for Selective Chemical Sensing
Organisms detect odors with great specificity and sensitivity using highly evolved olfactory systems. While the structure and specificity of olfactory organs and systems varies species to species, there are two common themes -- high surface area for interaction with odors and odorant receptor proteins for capture of specific odors. The combination of high surface area and odorant receptor proteins allows the detection of multiple odors that are of interest to the organism and that are present in a wide range of concentrations, for example the detection of different flower scents by insects. The insect olfactory organ, the antenna, is the bio-inspiration for our proposed research: fabrication of a highly sensitive and selective micromechanical sensor that uses both high surface area and specific capture proteins for odor detection. This new biosensors will be significantly more sensitive than current analogs and will enable earlier and more precise detection of volatile organic compounds. Such compounds are important for applications ranging from explosives detection to cancer diagnostics, therefore proposed technology will have significant societal impact.
Technical description: The proposed sensor platform, the micromechanical cantilever, will be fabricated with high surface area silicon dioxide nanostructure to which odorant receptor proteins will be tethered thereby mimicking the two principles widely found in biological olfactory systems. We will explore a fundamental cantilever-based sensing modality: dynamic-mode operation in which the mass of the bound odor molecules changes the frequency of a resonant cantilever. In an innovative approach, the silicon dioxide nanostructures are created using low-temperature glancing angle deposition (GLAD) of silicon dioxide in a post-processing manner, i.e. after the fabrication of the cantilever platforms. GLAD deposition facilitates fabrication of selectable (nanostructure elemental composition) and tunable (density, shape, aspect ratio) surface structure. Nanostructured surfaces will be locally functionalized with receptor peptides derived from human odorant receptor proteins sequences, which selectively bind the volatile organic compounds (VOCs) of interest. Microcantilever technology allows fabrication of multiple cantilever sensor arrays in which the elements of the array are individually functionalized to sense a number of target analytes simultaneously. This interdisciplinary project integrates biological sensing with micromechanical nanostructured sensors for low-level (parts per billion) detection of VOC analytes. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96203
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Karolyn Hansen. EAGER: Bio-Inspired Nanostructured Microsensor Arrays for Selective Chemical Sensing. 2013-01-01.
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