| 项目编号: | 1353737
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| 项目名称: | Identifying Genetic Determinants of Speciation from Genomic Maps of Ancestry in Hybrid Mice |
| 作者: | Bret Payseur
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| 承担单位: | University of Wisconsin-Madison
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| 批准年: | 2013
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| 开始日期: | 2014-08-01
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| 结束日期: | 2018-07-31
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| 资助金额: | USD899993
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | species
; research
; speciation
; hybrid
; ancestry junction
; genome
; genetic drift
; hybrid zone
; house mouse
; genetic architecture
; hybrid genome
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| 英文摘要: | Why are there so many species? The process by which two species are generated from one - speciation - is a major determinant of biodiversity. When species hybridize in nature, some parts of their genomes are exchanged and others are not. Those regions of the genome that are not exchanged keep the species separate. By identifying those incompatible regions in species of mice, this research will reveal genetic mechanisms responsible for speciation (and biodiversity). Another novel contribution of this research will be the development of new approaches that analyze entire genomes, instead of one region at a time. The project will combine research with teacher training to share discoveries with the public. In addition to expanding evolutionary knowledge, this research will benefit applied fields, including human health. For example, the framework developed in this project can be used to understand the current reproductive effects of historical mating between humans and Neanderthals.
This research will provide new theoretical and empirical frameworks for measuring gene flow between species in hybrid zones. The focus will be ancestry junctions - those points along chromosomes where ancestry switches from one species to the other. In contrast to existing analyses of hybrid genomes, this approach will easily scale to entire genomes. Computer simulations will be used to quantify the effects of selection, migration and genetic drift on ancestry junctions across the genome. A range of genetic architectures of reproductive isolation will be investigated to determine the conditions under which selection against hybrids leaves detectable genomic signatures. This theoretical framework will be applied to new genomic data collected in hybrids between two subspecies of house mice that are excellent models for studying speciation in progress. Incompatible genomic regions responsible for reproductive barriers between new species will be identified. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96234
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Bret Payseur. Identifying Genetic Determinants of Speciation from Genomic Maps of Ancestry in Hybrid Mice. 2013-01-01.
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