| 项目编号: | 1402984
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| 项目名称: | Sources of adaptation during BMI control |
| 作者: | Karen Moxon
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| 承担单位: | Drexel University
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| 批准年: | 2013
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| 开始日期: | 2014-07-15
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| 结束日期: | 2017-06-30
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| 资助金额: | USD299354
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | aim
; neuron
; task
; bmi
; volitional control
; spinal cord injury
; novel bmi paradigm
; rat
; activity
; work
; bmi controlthere
; project
; spinal transection
; innovative bmi paradigm
; neural adaptation
; neural control
; voluntary control
; closed-loop bmi system
; information
; bmi control
; extensive adaptation
; closed-loop bmi paradigm
|
| 英文摘要: | PI: Moxon, Karen A.
Proposal Number: 1402984
Institution: Drexel University
Title: Sources of adaptation during BMI control
There are currently over 270,000 people who have sustained a debilitating spinal cord injury costing the nation $9.73 billion per year on healthcare and lost productivity. Most of these people are paralyzed from at least the waist down and restoring voluntary control of their legs is among their most desired outcomes. Importantly, significant advances have been made in developing improved stimulators that can activate nerves or muscles of the legs and restore movement. At the same time, scientists have demonstrated the ability to record the activity of neurons in the brain, decode information about the intention of a patient to move their limbs and then use that information to control a robotic device or exoskeleton. The goal of this project is to combine these technologies and develop optimal decoders that can "translate" the patterns of activity of neurons in the brain to information that could be used to control electrical stimulation and restore volitional control of the patients own legs. This work is important because it represents an innovative approach to restoring a patient?s autonomy after a debilitating spinal cord injury. A broader impact of this research is that this approach could likely be applied to other neurological disorders or diseases. Additional broader impacts include the fact that this work is part of a larger Neuroengineering Program at Drexel University that both trains students and develops outreach programs. This project will contribute to the program by raising awareness about spinal cord injury while providing opportunities for students to participate in engineering design and development at all levels of education (K-12, undergraduate, graduate). Importantly, this is an interdisciplinary program involving engineers, biologists and neuroscientists in a team effort to solve a complex problem and special emphasis will be placed on the education of women and other underrepresented groups in science, technology and engineering.
To date, most brain-machine interface (BMI) studies have been done in healthy animal models. While these data show extensive adaptation of neurons to "learn" to control an external device, the problem is that extensive plasticity and reorganization occur after injury and the effects of this on BMI are unknown. The long-term goal of this project is to design effective decoders as part of a closed-loop BMI system that could control functional electrical stimulation after spinal cord injury to restore volitional control of a patient's own limbs. The central goal of this proposed work is to assess the relative role of the decoding algorithm compared to that of task complexity on neural adaptation both before and after complete spinal cord injury. This goal will be accomplished by using an innovative BMI paradigm that allows a rat to continuously interact with the decoder while performing a task 1) they are highly motivated to perform, 2) does not require training and 3) they can perform even after a complete spinal transection. The task requires the animal to maintain its balance in response to unexpected perturbations of posture using neural control (i.e. BMI). Using this novel BMI paradigm, the central goal of this proposal will be addressed with two Aims. Aim 1 is to identify computational mechanisms used by primary motor cortex for the control of balance. This Aim will be accomplished by comparing encoding mechanisms utilized by healthy rats to those of rats with spinal transection in the tilting task by recording and analyzing the activity of populations of single neurons, electromyography from hindlimb flexors and extensors and ground reaction forces. Aim 2 is to compare the adaptability of neurons during BMI control using different decoders and tasks. This Aim will be accomplished by comparing the adaptability of neurons recorded from healthy animals to those recorded from rats with spinal transection using variations of the tilting task in a closed-loop BMI paradigm. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96360
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Karen Moxon. Sources of adaptation during BMI control. 2013-01-01.
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