| 项目编号: | 1351947
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| 项目名称: | CAREER:Engineering Three-Dimensional Environments for the Generation of Functional Aortic Heart Valve Tissue |
| 作者: | Elizabeth Dirk
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| 承担单位: | University of New Mexico
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| 批准年: | 2013
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| 开始日期: | 2014-07-01
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| 结束日期: | 2019-06-30
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| 资助金额: | USD400000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | tissue engineering
; functional aortic heart valve tissue
; three-dimensional environment
; valve disease
; biomedical engineering
; biomass engineering program
; aortic heart valve tissue
; career award
; heart valve dysfunction
; valve replacement
; valve pathology
; current valve replacement
; aortic valve tissue
; biomedical engineering education
; tissue formation
|
| 英文摘要: | 1351947
Dirk, Elizabeth
This research will provide missing knowledge needed for the rational design of synthetic polymer environments to promote the production of functional aortic heart valve tissue. The community outreach focuses on biomedical engineering education from K-12 through graduate school. The research group assists in the exposure to and understanding of biomedical engineering to both teachers and students at a local minority-majority high school through talks, mentoring of problem based learning activities, and laboratory experiences. At the college level, a new educational track in biomechanics, biomaterials, and tissue engineering is being developed at the PhD level. This program will be the first university program with this focus in the state, and should lead to interest in this area of study for students in New Mexico.
Tissue engineering holds tremendous potential for regenerating aortic heart valve tissue for use in place of artificial materials during valve replacement. A number of existing natural and synthetic materials have been examined for use as the biodegradable scaffolds for the in vitro generation of aortic valve tissue. However, none have been truly successful due to an incomplete understanding of the resident cell population, valvular interstitial cells (VICs). To that end, the objective is to systematically examine the effects of biomaterial chemical functionality on VIC attachment, growth, and tissue formation in three-dimensional environments, both alone and in co-culture systems with valvular endothelial cells. The research will provide missing knowledge needed for the rational design of synthetic polymer environments to promote the production of functional aortic heart valve tissue. Once tissue engineered valves become available, there is promise that complications associated with current valve replacements could be overcome. Additionally, a greater understanding of VIC behavior and regulation could lead to the elucidation of the initiating events of valve pathologies associated with overproduction of extra-cellular matrix (ECM). Thus, the work may lead to important advances in long-term therapies for heart valve dysfunction. It is also anticipated that the generated knowledge will be equally applicable to understanding and preventing the onset of valve disease.
This CAREER award by the Biotechnology, Biochemical, and Biomass Engineering Program of the CBET Division is co-funded by the Biomaterials Program of the Division of Materials Research and by the Office of the Experimental Program to Stimulate Competitive Research (EPSCoR). |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96394
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Elizabeth Dirk. CAREER:Engineering Three-Dimensional Environments for the Generation of Functional Aortic Heart Valve Tissue. 2013-01-01.
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