| 项目编号: | 1403871
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| 项目名称: | Confinement, Dynamics, and Orientation of DNA at Nano-interfaces |
| 作者: | Alex Smirnov
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| 承担单位: | North Carolina State University
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| 批准年: | 2013
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| 开始日期: | 2014-07-01
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| 结束日期: | 2018-06-30
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| 资助金额: | USD300000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | nano-biosensor
; dna-nano-interface
; dna sequence
; nanoscale
; gold nanoparticle
; nanoparticle-dna interaction
; dna molecule
; dna helix
; dna-based material
; dna-nanoparticle interaction
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| 英文摘要: | DNA molecules are building blocks of the genetic code and are detected frequently to diagnose a range of diseases from cancer to infections. Understanding of how DNA organizes on the surface of the biosensor is important in order to develop better, more sensitive and specific diagnostic assays. This project will gain such understanding through a combination of theory and experiments.
Technical description:
This project will combine experimental and theoretical efforts to study interactions of DNA helices with gold nanoparticles. Nanoparticles emerge as promising new tools for experimental biology and nanomedicine because of the unusual surface chemistry and effect of shape at the nanoscale on the nanoparticle-DNA interactions. This collaborative project is designed to fill the existing void of data by combining experimental spectroscopic and biophysical studies with atomistic-level theoretical simulations. Specific efforts will be applied to systematic investigation of the effects of surface chemistry, DNA sequence, and presence of ions on DNA-nanoparticle interactions and binding. The experimental studies will provide an essential feedback for the theoretical models. Taken together, these studies will provide fundamental knowledge of DNA-nano-interface thus, enabling further development of nano-biosensors, DNA-based materials, and novel approaches for gene therapy, ultimately, contributing to improving quality of life. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96472
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Alex Smirnov. Confinement, Dynamics, and Orientation of DNA at Nano-interfaces. 2013-01-01.
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