| 项目编号: | 1438255
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| 项目名称: | Hydrodynamics of Self-Propelled Deformable Cells |
| 作者: | Prosenjit Bagchi
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| 承担单位: | Rutgers University New Brunswick
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| 批准年: | 2013
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| 开始日期: | 2014-07-01
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| 结束日期: | 2018-12-31
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| 资助金额: | USD384215
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | cell
; streaming flow
; deformable cell
; deformable membrane
; plant cell
; cell membrane
; dynamic cell shape
; live amoeboid cell
; malignant cell
; 2-component quasi-instantaneous intra-cellular velocity field
; biological cell
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| 英文摘要: | PI: Bagchi, Prosenjit
Proposal Number: 1438255
The objective of the proposed work is to study the propulsion of biological cells that utilize their extremely deformable membrane to move. Cells can deform and extend a protrusion, called pseudopod, by streaming flow internally in a particular direction of the cell membrane, and the pseudopod is used to move the cell. This is a proposal to study the pseudopod-based propulsion of deformable cells from a fluid mechanical viewpoint using a combination of high-fidelity computational modeling, theoretical analysis and experimental measurements. In terms of impact on health, the project may provide a mechanistic understanding of how to inhibit propulsive mechanisms of malignant cells.
While fluid mechanical analysis of the streaming flow has been carried out recently in plant cells, which are non-deforming and non-propulsive, the relationship between the streaming flow, pseudopod dynamics, and motor activity is unknown in deformable cells. The co-PIs propose to develop a multiscale, 3D computational model of the interface deformation driven by molecular motors. The model will predict simultaneously the dynamic cell shape, the flow field, and motor activity. In parallel, micro-PIV experiments will be performed in live amoeboid cells to extract the 2-component quasi-instantaneous intra-cellular velocity field. Using analysis of the simulation and experimental data, the nature and origin of the streaming flow in deforming cells, and its relation to pseudopod dynamics will be explored.
This award by the Fluid Dynamics Program of the CBET Division is co-funded by the Computational Mathematics Program in the Division of Mathematical Sciences. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96528
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Prosenjit Bagchi. Hydrodynamics of Self-Propelled Deformable Cells. 2013-01-01.
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