| 项目编号: | 1351474
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| 项目名称: | CAREER: Imaging multi-scale viscoelastic properties of cancer-associated remodeling |
| 作者: | Amy Oldenburg
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| 承担单位: | University of North Carolina at Chapel Hill
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2019-05-31
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| 资助金额: | USD400000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | bulk viscoelastic property
; imaging system
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| 英文摘要: | #1351474
P.I.: Amy L. Oldenburg
The PI proposes to construct a novel integrated system that incorporates optical coherence tomography (OCT), a method for visualizing cross-sections of cells in thick tissues, with in-line digital holography to rapidly image in-plane motions near the tissue surface. The OCT component will monitor light scattering fluctuations from diffusing gold nanorods which act as probes of the nanotopological environment. The holography component will capture induced surface elastic waves, which will be reconstructed into high resolution tissue elastograms. Integration of these imaging systems enables coregistration of driven and diffusive motions at multiple length scales in order to relate subcellular architecture with bulk viscoelastic properties. The proposed integrated system will be employed to study an early-stage breast cancer tissue culture model in which normal and pre-malignant mammary epithelial cells (MECs) are co-cultured with stromal fibroblasts. Measuring the microscale extracellular matrix stiffness in conjunction with nanorheological measurements in and around MECs and stromal cells will provide new insight into the biophysical processes that lead to breast cancer. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96651
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Amy Oldenburg. CAREER: Imaging multi-scale viscoelastic properties of cancer-associated remodeling. 2013-01-01.
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