| 项目编号: | 1354184
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| 项目名称: | COLLABORATIVE RESEARCH: Ecological consequences of the effects of a zoonotic pathogen on its reservoir host |
| 作者: | Dustin Brisson
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| 承担单位: | University of Pennsylvania
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2018-06-30
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| 资助金额: | USD369999
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | pathogen
; mouse
; potential unintended consequence
; scientific research
; lyme disease
; research experience
; human
; bacterial pathogen
; forest ecosystem?this research
|
| 英文摘要: | Many infectious diseases of humans are caused by pathogens that are transmitted from wildlife. One important example is Lyme disease, in which the bacterial pathogen lives inside small mammals, such as the white-footed mouse, and is transmitted to people by ticks that first bite an infected mouse and then a person. Human risk of Lyme disease increases with the abundance of white-footed mice. Recent data collected by the investigators suggest that mice infected with the Lyme disease bacterium live, on average, 17% longer than do uninfected mice. This is an unexpected finding, given that the bacterium causes illness in people and other animals. It is important because longer life spans likely result in larger populations of infected mice. How might the bacterium increase life span in mice and what are the consequences for disease transmission to other mammals (including humans) and for the forest ecosystem?
This research will experimentally determine the effects of the Lyme bacterium on: (1) mouse survival and abundance; (2) mouse foraging behavior; (3) how commonly mice are bitten by ticks; (4) the rate at which other (non-mouse) hosts for the tick become infected; and (5) the ability of mice to control populations of an exotic forest pest, the gypsy moth.
The proposed research will provide both content material and research experiences for the Community Science program at the University of Pennsylvania. This program is designed to increase the understanding of biology by high school teachers in inner-city Philadelphia schools and to expose high school students to scientific research and careers in science.
Lyme disease is a common and serious problem for humans in North America and elsewhere. The investigators will develop and test a vaccine to protect mice species from the pathogen that causes the disease. If this vaccine works as expected, it may reduce transmission of the pathogen to humans. Through a carefully designed experiment on wild mice, the investigators will be able to evaluate both the intended and potential unintended consequences of wildlife vaccination. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96699
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Dustin Brisson. COLLABORATIVE RESEARCH: Ecological consequences of the effects of a zoonotic pathogen on its reservoir host. 2013-01-01.
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