| 项目编号: | 1406254
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| 项目名称: | DISSERTATION IMPROVEMENT GRANT: Identifying Reproductive Isolation Loci from Clines in Hybrid Zones |
| 作者: | Bret Payseur
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| 承担单位: | University of Wisconsin-Madison
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2016-05-31
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| 资助金额: | USD19565
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | hybrid zone
; hybrid incompatibility locus
; incompatibility
; speciation
; process
; crop improvement
; doctoral dissertation research training
; population
; hybrid incompatibility
|
| 英文摘要: | The emergence of new species from others is a captivating topic for evolutionary biologists and non-scientists alike. Speciation occurs when genetic differences called incompatibilities accumulate between populations reducing the fitness of progeny of parents from different populations. This research will develop new approaches to analyze genomic signatures of incompatibilities during the process of speciation. Progress in understanding the genetic basis of speciation will improve efforts in wildlife conservation, crop improvement, and given recent evidence that humans and Neanderthals interbred, human evolution and medical genetics. The software and approaches developed will be freely available and provide guidance for similar studies conducted on other taxa. This grant also facilitates an international collaboration with a German researcher, and doctoral dissertation research training for a first generation college graduate. Finally, speciation is a topic that is fundamental to understanding the process of evolution. The researchers regularly participate in outreach events including public lectures and events for K-12 teachers and students.
Early in the process of speciation incompatibilities are uncommon and populations may cross in a region called a hybrid zone. Such hybrid zones provide rare opportunities to search for incompatibilities and to understand the speciation process. Unfortunately, analysis of incompatibilities in hybrid zones is limited by the methods currently available for analyzing recently available genomic data. The task is complicated by historical factors of populations that mimic or mask the effects of selection against hybrids in genome sequences. The mouse subspecies complex, Mus musculus spp., offers a unique opportunity to study laboratory mapped hybrid incompatibility loci in a natural hybrid zone. Numerous hybrid incompatibility loci have been mapped in laboratory crosses between M. m. musculus and M. m. domesticus. These two species also form a stable hybrid zone in central Europe. This project will use cline methods to test whether hybrid incompatibility loci discovered in laboratory crosses exhibit reduced gene flow in the mouse hybrid zone. Because current analytical methods are not well designed to detect interactions between alleles of the kind found in the laboratory studies and do not consider the complex demographic factors of hybrid zones, the research includes computer simulations of hybrid incompatibilities segregating in hybrid zones and measures their effects on clines using currently available methods, as well as methods developed as part of this project. The new methods will be tested by the field studies. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96730
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Bret Payseur. DISSERTATION IMPROVEMENT GRANT: Identifying Reproductive Isolation Loci from Clines in Hybrid Zones. 2013-01-01.
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