| 项目编号: | 1407078
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| 项目名称: | DISSERTATION RESEARCH: A case study of evolution of epigenetic regulators post-gene duplication: Understanding EMBRYONIC FLOWER2-mediated gene regulation in a moss |
| 作者: | Chelsea Specht
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| 承担单位: | University of California-Berkeley
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2016-05-31
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| 资助金额: | USD20337
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | emf2 gene
; evolution
; gene duplication
; study
; gene
; gene duplication event
; general public
; embryonic flower2
; novel genetic material
; model moss species
; gene activation
; new gene
; plant evolution
; phylogenetic analysis
; developmental evolution
; duplicated gene
; moss lineage
; gene regulation
; regulatory gene change
; important gene regulator
; emf2-mediated gene regulation
; duplication event
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| 英文摘要: | Gene duplication is an important source of novel genetic material on which evolution can act. The novel functions may partially include the original function or may be entirely novel. In the case of the EMBRYONIC FLOWER2 (EMF2) proteins in mosses, the newly duplicated genes may target new genes for repression or they may each target a subset of the original targets. This study is of scientific importance because it will serve as a model to understand how the function of regulatory genes change after a gene duplication event. Moreover, the EMF2 proteins are part of a protein complex that is important in controlling the life cycles of land plants. Thus, understanding the evolution of EMF2-mediated gene regulation will provide a better understanding of the developmental evolution of terrestrial plant life. The EMF2 genes, however, are not only important in plant evolution- they are necessary in animal development. Humans with mutated EMF2 genes or with the wrong amount of EMF2 protein will often develop cancer. Although humans and plants are distantly related, uncovering the conserved mechanisms behind EMF2 gene regulation will contribute to our understanding of human disease. Additional impacts include mentoring and training of undergraduates, along with outreach to K-12 schools and the general public.
Gene duplication is important because it is the primary mechanism through which novel protein functions arise. This study aims to understand the role gene duplication has played in the evolution of gene regulation. The EMF2 genes are important gene regulators, ensuring that genes are turned off and remain off at the appropriate time during development. The EMF2 genes have undergone duplications during the evolution of many plant lineages. One set of duplication events has produced three copies of the EMF2 genes in Physcomitrella, a model moss species for which powerful genetic and genomic resources are available. The goals of this project are: 1) To understand the evolution of the EMF2 genes in the moss lineage by phylogenetic analysis of gene duplication events; 2) To understand the function of each of the three Physcomitrella EMF2 genes by analyzing mutants in these genes; and 3) To understand how the Physcomitrella gene duplications have modified the EMF2 gene regulation mechanism by determining which genes are targeted by each EMF2 copy and by determining whether this EMF2 targeting results in gene activation or repression. Overall, this study will provide an understanding of the evolution of gene regulation post-gene duplication. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96736
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Chelsea Specht. DISSERTATION RESEARCH: A case study of evolution of epigenetic regulators post-gene duplication: Understanding EMBRYONIC FLOWER2-mediated gene regulation in a moss. 2013-01-01.
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