| 项目编号: | 1407000
|
| 项目名称: | Dissertation Research: Genetic Architecture of Adaptive Evolution in Mitochondrial Physiology |
| 作者: | Walter Eanes
|
| 承担单位: | SUNY at Stony Brook
|
| 批准年: | 2013
|
| 开始日期: | 2014-06-01
|
| 结束日期: | 2017-05-31
|
| 资助金额: | USD18743
|
| 资助来源: | US-NSF
|
| 项目类别: | Standard Grant
|
| 国家: | US
|
| 语种: | 英语
|
| 特色学科分类: | Biological Sciences - Environmental Biology
|
| 英文关键词: | genetic architecture
|
| 英文摘要: | Genetic architecture is the pattern and organization of genetic effects controlling phenotypic variation. I take an experimental approach to dissecting genetic architecture for the bioenergetic process of oxidative phosphorylation, a metabolic pathway central to energy use. Using the fruit fly, Drosophila melanogaster, I will systematically alter each of the enzymes involved in this pathway, and then measure the effect on the flow of electrons through the whole respiratory chain. Because these effects define the genetic architecture of this pathway and determine the response to natural selection, I hypothesize that the strength of the effect dictates the mode of selection acting on genes of the respiratory chain and membrane lipid metabolism. This metabolic control hypothesis makes explicit predictions for molecular patterns of polymorphism and divergence which I will test using genomic data from D. melanogaster and D. simulans.
A major goal of modern biology is understanding the complexity of phenotypes and their underlying genetic architecture. Purely statistical approaches to genetic architecture of complex traits (e.g., cardiovascular disease) have had mixed success. The type of metabolic control analysis done in this study is routinely used to diagnose metabolic and mitochondrial pathologies. By quantifying the full control distribution for this complex trait we may better uderstand the causes of such diseases. In addition, this project will involve the mentoring of undergraduate students. |
| 资源类型: | 项目
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96771
|
| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
|
|
There are no files associated with this item.
|
| Recommended Citation: | |
Walter Eanes. Dissertation Research: Genetic Architecture of Adaptive Evolution in Mitochondrial Physiology. 2013-01-01.
|
|
|