globalchange  > 影响、适应和脆弱性
项目编号: 1401143
项目名称:
DISSERTATION RESEARCH: Invasion phylogeography of Borrelia burgdorferi, a tick-borne pathogen
作者: Maria Diuk-Wasser
承担单位: Yale University
批准年: 2013
开始日期: 2014-06-01
结束日期: 2015-05-31
资助金额: USD21146
资助来源: US-NSF
项目类别: Standard Grant
国家: US
语种: 英语
特色学科分类: Biological Sciences - Environmental Biology
英文关键词: pathogen ; invasion history ; ongoing invasion ; important human pathogen
英文摘要: Tick-borne diseases pose a significant and growing global health burden due to the expanding range of tick vectors, reservoir hosts, and pathogens, as well as a suite of other environmental pressures. Lyme disease is the most prevalent tick-borne disease in the US and the vast majority of cases occur in the Northeast. Over the past forty years, it has rapidly spread from southern New England through Maine as well as through the Upper Midwest. Despite its epidemiological importance, the source and trajectory of the ongoing invasion remains poorly described. This project harnesses the tools of next generation sequencing to reconstruct the evolutionary history of the Lyme disease bacteria, Borrelia burgdorferi. Surveying the genomic diversity of the pathogen will allow us to infer the probable origin of invasion and pathways of spread and will inform a better understanding of the environmental or ecological factors driving the emergence.

Resolving the invasion history of B. burgdorferi will inform models of continued spatial spread and targeted control measures for this important human pathogen. Further, this project will support the research of a team of three female scientists and the training of at least four undergraduate assistants, including women and minorities, and several high school students in field ecology, epidemiology, and evolutionary genomics techniques.
资源类型: 项目
标识符: http://119.78.100.158/handle/2HF3EXSE/96776
Appears in Collections:影响、适应和脆弱性
气候减缓与适应

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Recommended Citation:
Maria Diuk-Wasser. DISSERTATION RESEARCH: Invasion phylogeography of Borrelia burgdorferi, a tick-borne pathogen. 2013-01-01.
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