| 项目编号: | 1401014
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| 项目名称: | Dissertation Research: The role of gene duplication and symbiont association in the evolution of sea anemone venom |
| 作者: | Marymegan Daly
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| 承担单位: | Ohio State University
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2017-05-31
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| 资助金额: | USD19687
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | venom
; gene duplication
; sea anemone
; functional venom gene
; venom diversity
; medical research
; planned research
; genetic level
; duplicated gene
; extant venomous animal
; venom repertoire
; gene diversity
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| 英文摘要: | The diversity of venoms within a group of organisms is largely the product of gene duplication and subsequent DNA sequence diversification. The specifics of this process remain obscure in most organisms. The planned research uses sea anemones (Cnidaria: Anthozoa, Actiniaria) as a model to understand the genome-level processes like gene duplications in shaping venom repertoire. The incidence of gene duplication and the processes by which duplicated genes diversify or become non-functional can be inferred through the analysis of the sequences that flank functional venom genes and the regions of the genome in which venoms are particularly common.
Sea anemones are part of the oldest and largest group of extant venomous animals. Their venoms exhibit a variety of functions, including disrupting the control of ion channels, destabilizing cellular membranes, or inhibiting synthesis of lipids. The functional and structural diversity of venoms is underpinned by an even greater degree of diversity at the genetic level. This more detailed account of venom diversity thus has potential for studies of function and structure of venom, and may have applications of interest to pharmacological or medical research. Additional benefits to the broader community include the training of graduate and undergraduate students, outreach to general and technical audiences through presentations, and published scientific studies of gene diversity and evolution. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96809
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Marymegan Daly. Dissertation Research: The role of gene duplication and symbiont association in the evolution of sea anemone venom. 2013-01-01.
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