| 项目编号: | 1406762
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| 项目名称: | Dissertation Research: The role of genetic interactions in adaptation |
| 作者: | Paul Hohenlohe
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| 承担单位: | University of Idaho
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| 批准年: | 2013
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| 开始日期: | 2014-06-01
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| 结束日期: | 2016-05-31
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| 资助金额: | USD18823
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Biological Sciences - Environmental Biology
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| 英文关键词: | gene interaction
; epistatic interaction
; research career
; complex interaction
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| 英文摘要: | Many genes control organismal traits and these genes interact in complex ways. This project focuses on two types of gene interactions - physical and epistatic (gene-by-gene) - and how their contribution shapes biological diversity. First, genes are physically located along chromosomes so that the action of genetic recombination, mutation and selection on a focal gene affects expressed variation at nearby genes. Second, genes may interact with one another through common genetic pathways. We will evolve experimental populations of yeast in the laboratory under different environmental conditions, and then genetically sequence the populations to test a prevailing model of genetic evolution. We will also use computer simulation models of evolving genetic networks to identify how epistatic interactions affect adaptation to changing environmental pressures. Lastly, we will examine the joint effect of these two types of interactions on genetic diversity in the experimental yeast system.
This research will train a graduate student in genomics and experimental evolution, with mentorship toward a research career. Furthermore, we will create an educational webpage available to the public, aimed at high school biology students, that will interactively show how the complex interaction of various genetic and environmental processes shape biological diversity. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/96810
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Paul Hohenlohe. Dissertation Research: The role of genetic interactions in adaptation. 2013-01-01.
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