| 项目编号: | 1418831
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| 项目名称: | Investigating the Biological Function of Sterols and Hopanoids in Methylococcus capsulatus |
| 作者: | Paula Welander
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| 承担单位: | Stanford University
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| 批准年: | 2013
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| 开始日期: | 2014-02-15
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| 结束日期: | 2015-08-31
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| 资助金额: | USD120838
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Geosciences - Earth Sciences
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| 英文关键词: | sterol
; hopanoid
; physiological function
; earth
; methylococcus capsulatus
; sterol-like hopanoid
; lipid
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| 英文摘要: | The majority of life's history had been dominated by microbes whose metabolic inventions have significantly altered the Earth's surface environment and, in turn, impacted the evolution of life on Earth. Yet our ability to study microbial life in the context of the Earth's distant past has remained a difficult challenge primarily because microbes do not readily leave diagnostic morphological fossils. One of the predominant strategies to overcome this challenge has been the use of "molecular fossils." This approach correlates the occurrence of preserved lipids in ancient rocks with their production in modern bacteria. Two sets of lipids that have emerged as powerful geological biomarkers are sterols, produced primarily by eukaryotes, and the sterol-like hopanoids, produced only by bacterial species. In this project, investigators will study the biosynthesis and physiological function of both of these lipids in Methylococcus capsulatus. The ability to produce both sets of lipids is rarely observed in the bacterial domain. Therefore, this organism provides an excellent model system for examining the evolutionary and physiological significance of both hopanoids and sterols with the expectation that these studies will allow for a more informed and robust interpretation of the occurrence of sterols and hopanoids in the rock record. These studies will be carried out through a collaborative effort merging the fields of microbiology and organic geochemistry. The project will train an early career research scientist from an underrepresented minority group and a graduate student in the interdisciplinary field of geobiology. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/97343
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Paula Welander. Investigating the Biological Function of Sterols and Hopanoids in Methylococcus capsulatus. 2013-01-01.
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