| 项目编号: | 1350841
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| 项目名称: | EAGER: Fluorescence Studies of Surface Micro-heterogeneity in Thermoacidophile Lipid Membranes |
| 作者: | Parkson Chong
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| 承担单位: | Temple University
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| 批准年: | 2013
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| 开始日期: | 2014-01-01
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| 结束日期: | 2017-12-31
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| 资助金额: | USD185000
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| 资助来源: | US-NSF
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| 项目类别: | Standard Grant
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| 国家: | US
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| 语种: | 英语
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| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
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| 英文关键词: | functional heterogeneity
; liposome
; lipid-protein interaction
; stable lipid matrix
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| 英文摘要: | Abstract
#1350841
Chong, Parkson L.
Stable liposomes have many potential uses in drug formulations (and even skin-care products). Liposomes that can withstand autoclaving are especially desirable for medical applications. The PI proposes to investigate highly stable bipolar membranes (liposomes) with fluorescent tags that probe membrane properties at different membrane depths or at different lateral positions. Specifically, he hypothesizes that there should be significant structural and functional heterogeneities along the membrane normal and in the plane of the membrane, which are of critical importance in understanding membrane structure-function relationship for these ultra-stable architectures.
The results obtained from this research should enhance the understanding of lipid-protein interactions and solute permeation in archaeal membranes and will have profound implications in technological applications, such as extraordinarily stable lipid matrix for biosensors, light harvesting devices, and nanoparticles for targeted imaging and therapy. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/97515
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| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
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| Recommended Citation: | |
Parkson Chong. EAGER: Fluorescence Studies of Surface Micro-heterogeneity in Thermoacidophile Lipid Membranes. 2013-01-01.
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