| 项目编号: | 1341212
|
| 项目名称: | EAGER: Intra-operative detection and elimination of microscopic residual disease in drug- and radiation-resistant unresectable tumors |
| 作者: | Dmitri Lapotko
|
| 承担单位: | William Marsh Rice University
|
| 批准年: | 2013
|
| 开始日期: | 2014-01-01
|
| 结束日期: | 2015-12-31
|
| 资助金额: | USD300000
|
| 资助来源: | US-NSF
|
| 项目类别: | Standard Grant
|
| 国家: | US
|
| 语种: | 英语
|
| 特色学科分类: | Engineering - Chemical, Bioengineering, Environmental, and Transport Systems
|
| 英文关键词: | tumor recurrence
; pnb
; detection method
; unresectable hnscc tumor
; microscopic residual disease
; abstractthis eager proposal
|
| 英文摘要: | ABSTRACT
This EAGER proposal is aimed at the development of an adjuvant intra-operative therapeutic method that will address several critical needs for treatment of head and neck squamous cell carcinoma (HNSCC) as well as other cancer types to ensure clean surgical margins, prevent tumor recurrence, improve patients survival rates, and enhance their quality of life. This goal will be achieved through a novel plasmonic nanobubble (PNB) approach that combines intra-cellular application of four clinical modalities: encapsulated drugs (Doxil), gold nanoparticles (colloidal gold), near-infrared laser pulses of low energy, and X-rays. This method is referred to as quadrapeutics. The translation into clinical practice will be achieved through the folowing objectives: 1) Optimization of the PNB generation and detection methods in vivo and validation of the use of PNBs for the intra-operative diagnosis of MRD in mice. 2) Adopt the PNB and quadrapeutic methods for intraoperative adjuvant therapy of microscopic residual disease in unresectable HNSCC tumors in a mice model. |
| 资源类型: | 项目
|
| 标识符: | http://119.78.100.158/handle/2HF3EXSE/97517
|
| Appears in Collections: | 影响、适应和脆弱性
气候减缓与适应
|
|
There are no files associated with this item.
|
| Recommended Citation: | |
Dmitri Lapotko. EAGER: Intra-operative detection and elimination of microscopic residual disease in drug- and radiation-resistant unresectable tumors. 2013-01-01.
|
|
|