| 项目编号: | BB/N00194X/1
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| 项目名称: | Regulation of the male germline in cereal crops by somatic companion cells |
| 作者: | Jose F Gutierrez-Marcos
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| 承担单位: | University of Warwick
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| 批准年: | 2015
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| 开始日期: | 2016-21-03
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| 结束日期: | 2019-20-03
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| 资助金额: | GBP452812
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| 资助来源: | UK-BBSRC
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| 项目类别: | Research Grant
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| 国家: | UK
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| 语种: | 英语
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| 特色学科分类: | Agri-environmental science
; Genetics & development
; Plant & crop science
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| 英文摘要: | Like animals, most diploid plants reproduce sexually after going through genetic reduction (meiosis) to produce specialized haploid gametes (i.e. sperm cells and egg cells) within the male and female sex organs, respectively. However, the process by which plants establish haploid sexual lineages (or germlines) from diploid somatic tissues late in adult life is not yet understood, but is thought to involve large-scale developmental and whole-genome reprogramming. This proposal focuses on uncovering some of the mechanisms involved in this process. We have evidence that novel small-RNA binding Argonaute proteins (AGOs) specifically found in male reproductive organs of cereals and their associated class of small non-coding RNA molecules control the development of the male germline. Intriguingly, these AGOs are expressed in somatic cells surrounding the male germline and sperm cells, yet defects or mutations in these AGOs causes male sterility. In this proposal, we will use various approaches and experimental techniques (eg. developmental genetics, biochemistry, computational and molecular biology) to determine exactly how somatic companion cells regulate the fate of the male germline using two important model crop plants: maize and wheat. We anticipate that this work will not only advance our basic understanding of how plants set their male germline, but will also provide a novel strategy to engineer new breeding tools in agronomically important cereal crops. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/100427
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| Appears in Collections: | 科学计划与规划
气候变化与战略
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作者单位: | University of Warwick
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| Recommended Citation: | |
Jose F Gutierrez-Marcos. Regulation of the male germline in cereal crops by somatic companion cells. 2015-01-01.
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