DOI: 10.1016/j.watres.2018.01.027
Scopus记录号: 2-s2.0-85044635207
论文题名: Biotransformation of gabapentin in surface water matrices under different redox conditions and the occurrence of one major TP in the aquatic environment
作者: Henning N. ; Kunkel U. ; Wick A. ; Ternes T.A.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 137 起始页码: 290
结束页码: 300
语种: 英语
英文关键词: Biological transformation products
; Gabapentin
; Gabapentin-Lactam
; Potable water
; Water/sediment system
Scopus关键词: Mass spectrometry
; Potable water
; Biological transformation
; Environmental conditions
; Environmental persistences
; Gabapentin
; Gabapentin-Lactam
; High resolution mass spectrometry
; Transformation behavior
; Water/sediment systems
; Surface waters
; drinking water
; gabapentin
; lactam
; surface water
; 4 aminobutyric acid
; amine
; anticonvulsive agent
; cyclohexanecarboxylic acid derivative
; drinking water
; gabapentin
; gabapentin-lactam
; ground water
; heterocyclic compound
; spiro compound
; biotransformation
; byproduct
; chemical compound
; concentration (composition)
; environmental conditions
; laboratory method
; measurement method
; oxic conditions
; redox conditions
; sediment-water interface
; surface water
; aerobic metabolism
; amidation
; aquatic environment
; Article
; biodegradation
; biotransformation
; concentration (parameters)
; controlled study
; environmental monitoring
; liquid chromatography-mass spectrometry
; oxidation reduction reaction
; priority journal
; standard
; analysis
; biotransformation
; chemistry
; liquid chromatography
; metabolism
; oxidation reduction reaction
; river
; tandem mass spectrometry
; water pollutant
; Aerobiosis
; Amines
; Anticonvulsants
; Aza Compounds
; Biotransformation
; Chromatography, Liquid
; Cyclohexanecarboxylic Acids
; Drinking Water
; gamma-Aminobutyric Acid
; Groundwater
; Oxidation-Reduction
; Rivers
; Spiro Compounds
; Tandem Mass Spectrometry
; Water Pollutants, Chemical
英文摘要: Laboratory-scale incubation experiments in water/sediment systems were conducted to test the transformation behavior of the anticonvulsant gabapentin (GBP) under different environmental conditions (aerobic, anaerobic, with abiotic controls). GBP was transformed by biological processes as it was eliminated quickly under aerobic conditions (dissipation time 50% of initial concentration (DT50): 2–7 days) whereas no decrease was observed under anaerobic conditions. Measurements via high resolution mass spectrometry (LC-Orbitrap-MS) revealed eight biological transformation products (TPs). Three of them were identified with reference standards (GBP-Lactam, TP186, TP213), while for the other five TPs tentative structures were proposed from information by MS2/MS3 experiments. Furthermore, the quantitatively most relevant TP GBP-Lactam was formed via intramolecular amidation (up to 18% of initial GBP concentration). Incubation experiments with GBP-Lactam revealed a higher stability against biotic degradation (DT50: 12 days) in contrast to GBP, while it was stable under anaerobic and abiotic conditions. Besides GBP, GBP-Lactam was detected in surface water in the μg L−1 range. Finally, GBP and GBP-Lactam were found in potable water with concentrations up to 0.64 and 0.07 μg L−1, respectively. According to the elevated environmental persistence of GBP-Lactam compared to GBP and its presumed enhanced toxicity, we recommend to involve GBP-Lactam into monitoring programs. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112815
Appears in Collections: 气候减缓与适应
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作者单位: Department of Aquatic Chemistry, Federal Institute of Hydrology (BfG), Am Mainzer Tor 1, Koblenz, D-56068, Germany; Bavarian Environment Agency, Bürgermeister-Ulrich-Str. 160, Augsburg, 86179, Germany
Recommended Citation:
Henning N.,Kunkel U.,Wick A.,et al. Biotransformation of gabapentin in surface water matrices under different redox conditions and the occurrence of one major TP in the aquatic environment[J]. Water Research,2018-01-01,137