Public, Environmental & Occupational Health
; Tropical Medicine
WOS研究方向:
Public, Environmental & Occupational Health
; Tropical Medicine
英文摘要:
Malaria transmission in African highland areas can be prone to epidemics, with minor fluctuations in temperature or altitude resulting in highly heterogeneous transmission. In the Kenyan Highlands, where malaria prevalence has been increasing, characterising malaria incidence and identifying risk factors for infection is complicated by asymptomatic infection.
This all-age cohort study, one element of the Malaria Transmission Consortium, involved monthly follow-up of 3155 residents of the Kisii and Rachuonyo South districts during June 2009June 2010. Participants were tested for malaria using rapid diagnostic testing at every visit, regardless of symptoms.
The incidence of Plasmodium falciparum infection was 0.2 cases per person, although infections were clustered within individuals and over time, with the majority of infections detected in the last month of the cohort study. Overall, incidence was higher in the Rachuonyo district and infections were detected most frequently in 510-year-olds. The majority of infections were asymptomatic (58%). Travel away from the study area was a notable risk factor for infection.
Identifying risk factors for malaria infection can help to guide targeting of interventions to populations most likely to be exposed to malaria.
1.London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England 2.Evidence Act, Ngong Rd, Nairobi, Kenya 3.Kenya Med Res Inst KEMRI, KEMRI Wellcome Trust Res Programme, Kemri Sq, Kilifi, Kenya 4.Imperial Coll London, Praed St, London W2 1NY, England 5.Macha Res Trust, Choma, Southern Provin, Zambia 6.Bloomberg Sch Publ Hlth, Johns Hopkins Malaria Res Inst, Baltimore, MD USA
Recommended Citation:
Cook, Jackie,Owaga, Chrispin,Marube, Elizabeth,et al. Risk factors for Plasmodium falciparum infection in the Kenyan Highlands: a cohort study[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE,2019-01-01,113(3):152-159