The minimum and maximum temperatures in four national primary standards of the ground meteorological stations in Hotan region of south Xinjiang from 1960-2013 were examined to provide a scientific basis for short-term climate prediction, ecological environment security and disaster control. In order to analyze trends of the extreme temperature, the cumulative method, the method of monadic linear regression, and the Mann-Kendall mutation and Moler wavelet analysis method were used to analyze the temperature changes in the region. The results showed that: the minimum and the maximum temperature elevated obviously at the approximately 0.48℃/decade (p<0.01) and 0.19℃/decade (p<0.01),respectively, in Hotan Region in recent 54 years. The minimum temperature had fluctuated upward trend since the 1960s. Since the early 1960s, the maximum temperature fluctuations increased after the fall; in the late 1970s and the early 1980s, the maximum temperature trend wave rose, about the late 90s, it increased after the first drop in fluctuations. The minimum and maximum temperature presented the rising trend, variation was significant in the autumn and the contribution to the annual change was the largest. The annual mutation of maximum temperature occurred in 1997,but mutation phenomenon did no exist for minimum temperature. According to the study, it is found that the future development of the basin will be warm and wet.